Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD.

Medicine and Science in Sports and Exercise
Rongsong LiHarry B Rossiter

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with altered metabolism and body composition that accompany poor outcomes. We aimed to determine whether metabolic derangements in COPD are associated with skeletal muscle deconditioning and/or physical inactivity, independent of pulmonary obstruction. We characterized serum metabolites associated with muscle oxidative capacity or physical activity in 44 COPD patients (forced expiratory volume in 1 s [FEV1] = 61% ± 4% predicted) and 63 current and former smokers with normal spirometry (CON) (FEV1 = 93% ± 2% predicted). Medial gastrocnemius oxidative capacity was assessed at rest from the recovery rate constant (k) of muscle oxygen consumption using near-infrared spectroscopy. Step counts and physical activity (average vector magnitude units [VMU] per minute) were measured over 5-7 d using triaxial accelerometry. Untargeted prime and lipid metabolites were measured using liquid chromatography and mass spectrometry. Muscle k (1.12 ± 0.05 vs 1.68 ± 0.06 min, P < 0.0001, d = 1.58) and VMU per minute (170 ± 26 vs 450 ± 50 VMU per minute, P = 0.004, d = 1.04) were lower in severe COPD (FEV1 < 50% predicted, n = 14-16) compared with CON (n = 56-60). A total of 129 prime metabo...Continue Reading

References

Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Jun 9, 2005·American Journal of Respiratory and Critical Care Medicine·Hiroo WadaYorihiro Yamamoto
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Aug 2, 2005·Journal of Cardiopulmonary Rehabilitation·Karine MarquisPaul Poirier
Jan 22, 2008·European Journal of Epidemiology·Iris KompauerJoachim Heinrich
Feb 20, 2010·Respiratory Medicine·Thierry TroostersMarc Decramer
Aug 8, 2012·Trends in Cardiovascular Medicine·Lauren Gerard KochUlrik Wisløff
Mar 22, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Firas S AhmedR Graham Barr
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
May 30, 2014·American Journal of Respiratory and Critical Care Medicine·Eef D TelengaNick H T ten Hacken
Jul 27, 2014·The European Respiratory Journal·Anouk W VaesMartijn A Spruit
Oct 30, 2014·Metabolic Syndrome and Related Disorders·Suzana E TanniSergio A R Paiva
Dec 11, 2014·American Journal of Respiratory and Critical Care Medicine·Russell P BowlerKaterina Kechris
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Pieter A Leermakers, Harry R Gosker
Oct 23, 2016·Respiratory Physiology & Neurobiology·Alessandra AdamiHarry B Rossiter
Jan 4, 2017·The European Respiratory Journal·Brian L GrahamJack Wanger
Mar 31, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Benjamin WaschkiSabina Janciauskiene
Apr 1, 2017·Biology of Sex Differences·Sebastian RauschertChristian Hellmuth
May 4, 2017·Cell Metabolism·Bret H Goodpaster, Lauren M Sparks
May 23, 2017·International Journal of Molecular Sciences·Oliver J TaylorBenjamin T Bikman
Dec 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenji MizumuraIrina Petrache
Jul 29, 2018·Respiratory Medicine·Adolfo DomenechMiguel Ángel Sánchez-Chaparro
Jan 22, 2019·Clinical Nutrition ESPEN·Abril Jiménez-CepedaRocío Nayelí Sánchez-Santillán
May 20, 2019·Respiratory Research·Fernanda Machado RodriguesThierry Troosters
May 21, 2019·Journal of Cellular Physiology·Daniele FerraraFederico Carbone

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT00608764

Software Mentioned

COPDGene

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