Serum ADAMTS-13 Levels as an Indicator of Portal Vein Thrombosis

Gastroenterology Research and Practice
Tomasz MikułaAlicja Wiercińska-Drapało

Abstract

Coagulation disorders in patients with liver cirrhosis are a common clinical problem. Cirrhosis should be considered a state of impaired blood clotting or an imbalance of the whole coagulation system. Cirrhosis-induced coagulopathy encompasses disturbances in both the procoagulant and anticoagulant systems. This mechanism may promote the development of thrombosis with portal vein thrombosis (PVT), which is considered an obstacle to orthotopic liver transplantation (OLT). We assessed serum ADAMTS-13 levels in patients with decompensated liver cirrhosis, with and without PVT. Serum ADAMTS-13 levels, age, platelet count (PLT), and INR (international normalized ratio) were evaluated in (n = 64) patients with liver cirrhosis either with PVT (group 1, n = 31) or without PVT (group 2, n = 33). The results were compared with those from healthy volunteers (group 3, n = 37). Liver cirrhosis was based on Desmet's classification of chronic hepatitis in liver biopsy stage ≥ 3 or liver elastography F-score ≥ 3. Serum ADAMTS-13 levels were measured with Quantikine® ELISA Human ADAMTS13 Immunoassay, R&D Systems Inc. We used Welch's F-test, Games-Howell, one-way ANOVA, Bonferroni test, and logistic regression to determine whether ADAMTS-13 leve...Continue Reading

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Citations

Sep 10, 2019·World Journal of Gastroenterology : WJG·Mariella FacciaMaria Assunta Zocco
Mar 29, 2021·Journal of Thrombosis and Haemostasis : JTH·Dafna J GroeneveldJames P Luyendyk
Jul 2, 2021·Journal of Veterinary Internal Medicine·Michelle PavlickCynthia R L Webster

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Methods Mentioned

BETA
ELISA
biopsy

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