Serum adiponectin in breast cancer: A meta-analysis

Medicine
Li GuMing-Yao Chen

Abstract

Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent. A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size. Finally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population. The present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development.

References

Nov 8, 2002·Cancer Causes & Control : CCC·Libby M MorimotoAnne McTiernan
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Christos MantzorosDimitrios Trichopoulos
Jul 13, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D P RoseG D Stephenson
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Petra H LahmannElio Riboli
Jul 16, 2005·Cancer Letters·Da-Chung ChenShyng-Shou F Yuan
May 27, 2006·Endocrine-related Cancer·A M Lorincz, S Sukumar
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Anne E CustElio Riboli
Dec 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Antje KörnerChristos S Mantzoros
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Shelley S TworogerSusan E Hankinson
Feb 14, 2007·Journal of Korean Medical Science·Jee-Hyun KangDae-Sung Youn
Oct 21, 2009·Breast Cancer Research and Treatment·K HanckeJ M Weiss
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne EwertzSøren Cold
Feb 1, 2011·Cardiovascular Diabetology·Jan Westerink, Frank L J Visseren
May 17, 2011·Molecular Carcinogenesis·Paul A CarrollElizabeth M Connolly
Oct 5, 2011·Nutrition Reviews·Flávia M SilvaAna M Feoli
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Mehmet Ali GulcelikNese Ersoz Gulcelik
Sep 29, 2012·Vitamins and Hormones·Marie-France PalinBruce D Murphy
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Jonnathan G Santillán-BenítezAngel Ordóñez-Quiroz
Mar 8, 2013·Cancer Prevention Research·Nicholas J OllberdingMarc T Goodman
Mar 14, 2013·Menopause : the Journal of the North American Menopause Society·Maria DalamagaAntigoni Lekka
May 9, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amy L GrossKala Visvanathan
Aug 10, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jingjing YeGuoyue Yuan
Aug 31, 2013·PloS One·Li-Yuan LiuZhi-Gang Yu
Oct 25, 2013·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Young Ae ChoJeongseon Kim
Oct 30, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Machiko MinatoyaKoichi Hirata
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Ken KishidaIichiro Shimomura
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Aliasghar KeramatiniaAlireza Mosavi-Jarrahi
Apr 17, 2014·International Journal of Epidemiology·Debora MacisSara Gandini
May 16, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Adana A M LlanosPeter G Shields
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Syed Danish Haseen AhmedNaheed Akhter
Jul 18, 2015·Journal of the National Cancer Institute·Marc J GunterGloria Y F Ho
Apr 16, 2016·Cytokine & Growth Factor Reviews·Ganji Purnachandra NagarajuSubasini Pattnaik
Aug 16, 2016·The Breast : Official Journal of the European Society of Mastology·Georgia P GeorgiouAntonia Gounaris
Jul 22, 2017·Open Medicine·Hilal Kiziltunc OzmenOrhan Sezen
Aug 20, 2017·The Journal of Biological Chemistry·Amy LyonsRosemary O'Connor
Feb 13, 2018·Current Problems in Cancer·Jiajia Li, Xianghui Han

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Citations

May 6, 2019·Journal of Cellular Physiology·Yu-Xiang WangLi Qin
Aug 16, 2019·The Journal of Gene Medicine·Heba F PashaAhmed M Yehia
Oct 23, 2019·Current Obesity Reports·Gerasimos Socrates ChristodoulatosMaria Dalamaga
Jun 20, 2019·International Journal of Molecular Sciences·Andrea TumminiaLucia Frittitta
Feb 19, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Sebastiano AndòLoredana Mauro
Jul 8, 2020·Cancers·Ryan Kolb, Weizhou Zhang
Sep 18, 2020·Animals : an Open Access Journal From MDPI·Alberto Muñoz-PrietoAsta Tvarijonaviciute
Nov 26, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xueyao WuJiayuan Li
Jan 24, 2021·Diabetology & Metabolic Syndrome·Kartika W Taroeno-HariadiTeguh Aryandono
Mar 11, 2021·International Journal of Endocrinology·Grigorios PanagiotouEleni Papakonstantinou
Nov 14, 2020·International Journal of Molecular Sciences·María Del Pilar Chantada-VázquezCristina Núñez
Jul 17, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Ece Koc Yildirim, Muharrem Balkaya
Jun 3, 2021·International Journal of Molecular Sciences·Ersilia NigroLuigi Sapio

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

STATA

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