Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans

Diabetologia
C ThamerH Häring

Abstract

Fat-rich diets can acutely induce insulin resistance. Data from adiponectin knock-out mice suggest that this effect might be increased in the absence of adiponectin. In the present study we tested whether plasma adiponectin concentrations influence changes in insulin sensitivity induced by a short-term dietary intervention in humans. We analysed data from 27 healthy, non-obese men with normal glucose tolerance. These men ate a diet high in fat and a diet high in carbohydrates for three days each. The high-fat diet induced a significant drop in insulin sensitivity (determined by euglycaemic-hyperinsulinaemic clamp) compared to baseline (0.100+/-0.009 vs 0.083+/-0.007 micro mol.kg(-1).min(-1).(pmol.l(-1)), p=0.01). The drop in insulin sensitivity was more pronounced in subjects with low serum adiponectin (0.094+/-0.011 vs 0.077+/-0.010 micro mol.kg(-1).min(-1).(pmol.l(-1)), p=0.02) than in subjects with high serum adiponectin (0.103+/-0.011 vs 0.090+/-0.040 micro mol.kg(-1).min(-1).(pmol.l(-1)), p=0.16). In the whole group the high-carbohydrate, low-fat diet did not cause an increase in insulin sensitivity (0.095+/-0.007 vs 0.102+/-0.009 micro mol.kg(-1).min(-1).(pmol.l(-1)), p=0.06). However, insulin sensitivity was significantl...Continue Reading

References

May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jul 13, 2002·Lancet·Robert S LindsayJonathan Krakoff
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C ThamerH-U Häring

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Citations

Oct 1, 2009·Journal of Gastroenterology and Hepatology·Nicolas Lanthier, Isabelle A Leclercq
Mar 26, 2008·Journal of Endocrinological Investigation·O UkkolaC Bouchard
Aug 22, 2008·Digestive Diseases and Sciences·Elife ErarslanNuket Bavbek
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Melania Manco, Geltrude Mingrone
Apr 12, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M-J ShinJ H Lee
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Oct 14, 2005·Obesity Research·Evan S BerkJeanine B Albu
Apr 22, 2006·Aging Cell·Donald K IngramRafael deCabo
Nov 17, 2005·Journal of the National Cancer Institute·Esther K WeiChristos S Mantzoros
Aug 24, 2007·Clinical Science·Marie C Guldstrand, Caroline L Simberg
May 29, 2018·Scientific Reports·Dicky L TahaparyMaria Yazdanbakhsh

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