Serum adropin levels are reduced in patients with inflammatory bowel diseases.

Scientific Reports
Darko BrnićJosko Bozic

Abstract

Adropin is a novel peptide mostly associated with energy homeostasis and vascular protection. To our knowledge, there are no studies that investigated its relationship with inflammatory bowel diseases (IBD). The aim of this study was to compare serum adropin levels between 55 patients with IBD (30 Ulcerative colitis (UC) patients, 25 Crohn's disease (CD) patients) and 50 age/gender matched controls. Furthermore, we explored adropin correlations with IBD severity scores, hsCRP, fecal calprotectin, fasting glucose and insulin levels. Serum adropin levels were significantly lower in patients with IBD in comparison with the control group (2.89 ± 0.94 vs 3.37 ± 0.60 ng/mL, P = 0.002), while there was no significant difference in comparison of UC patients with CD patients (P = 0.585). Furthermore, there was a negative correlation between adropin and fecal calprotectin (r = -0.303, P = 0.025), whereas in the total study population, we found a significant negative correlation with fasting glucose levels (r = -0.222, P = 0.023). A multivariable logistic regression showed that serum adropin was a significant predictor of positive IBD status when enumerated along with baseline characteristics (OR 0.455, 95% CI 0.251-0.823, P = 0.009). Our...Continue Reading

References

Apr 2, 1999·Alimentary Pharmacology & Therapeutics·E CapristoG Gasbarrini
Jul 23, 2003·The American Journal of Gastroenterology·Jørgen JahnsenErling Aadland
Dec 24, 2005·Inflammatory Bowel Diseases·Nicole BregenzerL Cornelius Bollheimer
Apr 25, 2006·Inflammatory Bowel Diseases·William R Best
May 18, 2007·Clinical Pharmacology and Therapeutics·F SchinzariC Cardillo
Apr 2, 2008·Current Gastroenterology Reports·R Balfour Sartor, Marcus Muehlbauer
Jul 16, 2008·Inflammatory Bowel Diseases·James D LewisJonas H Ellenberg
Jul 19, 2008·World Journal of Gastroenterology : WJG·Hugh-J Freeman
Apr 29, 2009·Angiology·Necati DagliIbrahim H Bahcecioglu
Sep 21, 2010·Circulation·Fina LovrenSubodh Verma
Mar 10, 2011·The American Journal of Gastroenterology·Andres J YarurDaniel A Sussman
Dec 24, 2011·Fertility and Sterility·Antoni J Duleba, Anuja Dokras
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
Jan 15, 2013·Journal of Perinatal Medicine·Ebru CelikSuleyman Aydin
Jul 31, 2013·Gastroenterology·Simon P L TravisWilliam J Sandborn
Apr 15, 2014·Regulatory Peptides·Jens P Goetze, Jakob Albrethsen
Jun 6, 2014·European Journal of Gastroenterology & Hepatology·Huseyin KorkmazLevent Kebapcilar
Mar 5, 2016·Gut Microbes·Yava L Jones-Hall, Cindy H Nakatsu
Mar 13, 2016·Journal of Endocrinological Investigation·T KumeO G Calan
Sep 7, 2016·The American Journal of Emergency Medicine·Bedia GulenHüseyin Uyarel
Mar 10, 2017·Journal of Neurogastroenterology and Motility·Max J Schmulson, Douglas A Drossman
Mar 30, 2017·Experimental and Therapeutic Medicine·Ping WuPeiying Zhang
Jul 12, 2018·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Josko BozicZoran Dogas
Aug 24, 2018·Journal of Crohn's & Colitis·Andreas SturmUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Apr 21, 2019·Physiological Reports·Dharendra ThapaIain Scott
Sep 26, 2019·Scientific Reports·Ivana Tadin HadjinaJosko Bozic

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Citations

Dec 21, 2020·European Journal of Internal Medicine·Elżbieta Cecerska-HeryćBarbara Dołęgowska
May 1, 2021·Life·Dijana Boric-SkaroJosko Bozic

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

MedCalc

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