PMID: 7019318Aug 1, 1981Paper

Serum agglutinins to Eubacterium and Peptostreptococcus species in Crohn's and other diseases

The Journal of Hygiene
F Wensinck, J P van de Merwe

Abstract

Sera from patients suffering from Crohn's and other diseases and from healthy subjects were tested for agglutinins to anaerobic, gram-positive coccoid rods belonging to species of Eubacterium and Peptostreptococcus. Four strains labelled Eubacterium contortum (two strains), Eubacterium rectale and Peptostreptococcus productus were agglutinated by a higher percentage of sera from patients with Crohn's disease than from healthy subjects and from patients with liver and intestinal diseases (including ulcerative colitis), ankylosing spondylitis, granulomatous diseases, diseases of immunity and malignancies. The agglutinins were of the IgG and IgM classes and strain-specific; the titres were low. The results obtained with sera from patients with Crohn's disease and healthy people were subjected to discriminant analysis to estimate the probability, based on the combined results with the four strains, that a patient suffers from Crohn's disease. When sera giving an a posteriori probability greater than or equal to 0.95 (a priori probability = 0.5) were considered positive, the test with four strains had a sensitivity of 54% and a specificity of nearly 100%. The results with sera submitted for diagnosis showed that positive reactions i...Continue Reading

References

Jun 11, 1977·Lancet·G De GrooteC A Phillips
Feb 1, 1977·Journal of Clinical Ultrasound : JCU·J M WardS L Johnson
May 1, 1977·The American Journal of Tropical Medicine and Hygiene·D CamusA Capron
Jan 1, 1975·Antonie van Leeuwenhoek·F Wensinck
Jun 30, 1973·Lancet·D R Triger, R Wright
Dec 1, 1971·Journal of Pharmaceutical Sciences·H L Fung, T Higuchi
Mar 21, 1970·British Medical Journal·N H Dyer, A M Dawson
Aug 1, 1981·The Journal of Hygiene·F WensinckA M Schröder

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Citations

Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robert M NakamuraMary Barry
Aug 1, 1981·The Journal of Hygiene·F WensinckA M Schröder
Apr 1, 1995·Journal of Clinical Pathology·M Oudkerk PoolA S Peña
Apr 1, 1984·Irish Journal of Medical Science·G F McCoyF Wensinck
Jul 1, 1994·Cytometry·L A van der WaaijD van der Waaij
Aug 1, 1984·The Journal of Hygiene·M P HazenbergJ P Van de Merwe
Feb 6, 1999·Histopathology·C M EdwardsB Warren
Mar 1, 1983·Scandinavian Journal of Gastroenterology·I O AuerH Schmidt
Nov 1, 1988·Scandinavian Journal of Gastroenterology·J P Van de MerweM P Hazenberg
Oct 1, 1986·Journal of Clinical Pathology·K BullJ Rhodes
Jan 1, 1984·Antonie van Leeuwenhoek·J P van de Merwe
Jan 5, 2002·Scandinavian Journal of Gastroenterology. Supplement·R K LinskensS G Meuwissen
Aug 1, 1985·European Journal of Immunology·J P Van de Merwe, J H Stegeman
Jan 1, 1986·Infection and Immunity·S A StimpsonJ H Schwab

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