Serum alanine aminotransferase elevation during 10 days of acetaminophen use in nondrinkers.

Pharmacotherapy
Kennon HeardRichard C Dart

Abstract

To describe the changes in serum alanine aminotransferase (ALT) levels in nondrinkers receiving acetaminophen for 10 days. Prospective, open-label study. Outpatient clinical research center. Twenty-four healthy volunteers who reported an average alcohol consumption of less than one drink/day for the 30 days preceding study enrollment. Patients were administered acetaminophen 4 g/day for 10 days (study days 1-10). Serum ALT level, total bilirubin level, and international normalized ratio (INR) were measured on study days 0, 4, 7, 9, 11, and 14. Median ALT level increased from 24 U/L on day 0 to 39 U/L on day 7, and remained elevated through day 11 (39 U/L); these increases were statistically significant (p=0.0002). Median ALT level began to trend down by day 14 (35 U/L). Fourteen subjects (58%) had ALT levels above the upper limit of normal; the largest elevation was 3.8 times the upper limit of normal (day 7). No increases in INR or total bilirubin level were noted during the study, and no subject developed symptoms of liver injury (e.g., abdominal pain, jaundice). Daily use of acetaminophen at the maximum dose of 4 g/day for 10 days caused asymptomatic ALT level elevations in subjects who do not consume alcohol. The clinical i...Continue Reading

References

Jan 13, 2006·The American Journal of Gastroenterology·George N IoannouSum P Lee
May 19, 2006·Journal of Gastroenterology and Hepatology·Chalamalasetty Sreenivasa BabaGourdas Choudhuri
Jul 6, 2006·JAMA : the Journal of the American Medical Association·Paul B WatkinsStephen C Harris
Mar 18, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Susan BartelsJulie Richard
Jan 9, 2009·Clinical Pharmacology and Therapeutics·J R Senior

❮ Previous
Next ❯

Citations

Mar 16, 2011·BMC Gastroenterology·Kennon J HeardRichard C Dart
Mar 19, 2013·Expert Opinion on Pharmacotherapy·Daniel J Niven, Kevin B Laupland
Oct 21, 2011·Expert Opinion on Drug Safety·Eric J LavonasRichard C Dart
Nov 14, 2012·British Journal of Clinical Pharmacology·Emma J TurtleDavid J Webb
Sep 14, 2013·Mitochondrion·M AdevaC Donapetry
May 4, 2016·Gastroenterología y hepatología·Miguel Bruguera
Feb 23, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Harry EganAngela L Chiew
Oct 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joel H VazquezMitchell R McGill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.