Serum alanine aminotransferase is associated with serum adiponectin, C-reactive protein and apolipoprotein B in young healthy men

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
T KazumiG Yoshino

Abstract

Several studies have reported an association between markers of liver injury, including elevated concentrations of alanine aminotransferase (ALT) aspartate aminotransferase (AST), and prospective risk of type 2 diabetes. We therefore examined the relationship between ALT and AST on the one hand, and serum adiponectin and highly sensitive CRP on the other, both of which have been reported to be associated with prospective risk of type 2 diabetes; we also tested for variable components of metabolic syndrome in 198 male college students aged 18-20 years. ALT showed a positive relationship with percentage body fat (r = 0.19, p = 0.02), serum leptin (r = 0.21, p = 0.01), LDL cholesterol (r = 0.29, p = 0.0003), triglyceride (r = 0.28, p = 0.0004) and apolipoprotein B (r = 0.35, p < 0.0001) even after adjustment for body mass index (BMI). Although there was a significant relationship with serum insulin, adiponectin (inversely), homeostasis model assessment of insulin resistance, systolic and diastolic blood pressure, HDL cholesterol (inversely) and LDL particle diameter in simple regression analysis, significance disappeared after adjustment for BMI. In contrast, CRP (r = 0.16, p = 0.04) was associated with ALT after adjustment for BM...Continue Reading

Citations

Feb 3, 2011·Hepatology International·Tary A SalmanOmkolsoum M El-Haddad
Dec 5, 2009·World Journal of Gastroenterology : WJG·Yu-Cheng LinPau-Chung Chen
Feb 4, 2014·Diabetes & Metabolism·T E SilvaL L Schiavon
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Dec 11, 2007·Archives of Medical Research·Daniel Antonio de LuisDiego Bellido
Dec 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy
Apr 4, 2021·International Journal of Environmental Research and Public Health·Reiko KurodaYasushi Suwazono
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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