Serum Alanine Aminotransferase Trends and Their Relationship with Obesity and Metabolic Syndrome in United States Adolescents, 1999-2014

Metabolic Syndrome and Related Disorders
Cyrelle R FerminMark D DeBoer

Abstract

Nonalcoholic fatty liver disease (NAFLD), characterized by hepatocyte dysfunction, fat accumulation, and fibrosis, is the most common cause of chronic liver disease in children. Elevated levels of serum alanine aminotransferase (ALT) are used clinically to identify potential liver dysfunction. Our goal was to assess for changes in the national prevalence of elevated ALT over time and potential relationship to trends in the metabolic syndrome (MetS) severity and elevated body mass index (BMI). We studied 5411 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 with complete MetS Z-score and ALT data from the National Health and Nutrition Examination Survey 1999-2014. Elevated ALT levels were defined by two different cutoffs: one for both sexes (30 U/L) and another that was sex specific (22 U/L girls; 25 U/L boys). MetS severity was assessed using a sex- and race-/ethnicity-specific MetS Z-score. We did not find a statistically significant linear increase in either mean ALT or the prevalence of elevated ALT differed over time. As expected, ALT levels were significantly correlated with BMI Z-score and MetS Z-score (P < 0.0001). Over time, BMI Z-scores increased and MetS severity Z-score decreased. Prevalenc...Continue Reading

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Citations

Mar 28, 2018·Metabolic Syndrome and Related Disorders·Linda X WangMark D DeBoer
Aug 18, 2018·Expert Review of Gastroenterology & Hepatology·Grace HattonJake P Mann
Jul 4, 2018·Minerva pediatrica·Linda X WangMark D Deboer
Mar 17, 2020·Pediatric Research·Sonimar de SouzaJane D P Renner
May 16, 2020·Gastroenterology Research and Practice·Jing ZhangZan Ding
Jul 11, 2019·Metabolic Syndrome and Related Disorders·Arthur M LeeMark D DeBoer

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS

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