Serum Alanine Transaminase as a Predictor of Type 2 Diabetes Incidence: The Yuport Prospective Cohort Study.

The Tohoku Journal of Experimental Medicine
Yu HatanoKimihiko Akimoto

Abstract

Prior studies have shown an association between the incidence of diabetes with liver enzymes, such as alanine transaminase (ALT). Liver fibrosis scores, such as the Fibrosis-4 index which indicates chronic liver damage, were also associated with diabetes development. However, no literature compared predictive accuracy between ALT and Fibrosis-4 index. Thus, we aimed to determine it, and to assess its association using inverse probability of treatment weighting. This was a non-concurrent prospective cohort study of 9,748 subjects without diabetes receiving Yuport Health Checkup in Japan between 1998 and 2006. ALT was categorized into three groups: the highest ALT group (men ≥ 30 U/L and women ≥ 20 U/L), the middle (men ≥ 20 and < 30 U/L, and women ≥ 14 and < 20 U/L), and the lowest (men < 20 U/L and women < 14 U/L). The primary outcome was the new onset of diabetes. The area under the receiver operating characteristic curves (AUC) of ALT for predicting the diabetes development was higher than that of any other markers of liver damage. The AUC for ALT was 0.71, while that for the Fibrosis-4 index was 0.51 (p < 0.001 for the difference between the AUCs). The highest and middle ALT groups had a significantly higher incidence of dia...Continue Reading

References

Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Jan 5, 2002·Diabetes Research and Clinical Practice·Takeshi KuzuyaUNKNOWN Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Feb 18, 2003·Journal of Epidemiology·Masako OkamotoZentaro Yamagata
Feb 20, 2003·Journal of Hepatology·Scott L Friedman
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Feb 19, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·K WakiUNKNOWN JPHC Study Group
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Jun 19, 2007·Genes & Development·Mohammed Qatanani, Mitchell A Lazar
Nov 4, 2008·Journal of Hepatology·Paul CalèsFrançoise Lunel
Jun 16, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amy G ShahUNKNOWN Nash Clinical Research Network
Nov 17, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Stanley XuDavid Smith
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
Nov 26, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·K InoueK Akimoto
Feb 13, 2010·Journal of Atherosclerosis and Thrombosis·Atsushi HozawaHirotsugu Ueshima
Apr 21, 2010·Experimental Biology and Medicine·Misuzu FujitaAkira Hata
Jun 10, 2010·Expert Review of Gastroenterology & Hepatology·Emma Brandish, Nick Sheron
Jul 7, 2011·World Journal of Hepatology·Takumi KawaguchiMichio Sata
Dec 14, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·K InoueK Akimoto
Mar 20, 2013·Diabetes Research and Clinical Practice·UNKNOWN IDF Diabetes Atlas Group
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Oct 19, 2010·Journal of Diabetes Investigation·Yutaka SeinoKohjiro Ueki
Feb 4, 2016·Epidemiology·Peng Ding, Tyler VanderWeele
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association
Dec 21, 2016·The American Journal of Gastroenterology·Paul Y KwoJoseph K Lim
Feb 16, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tyler Williamson, Pietro Ravani
May 16, 2019·Diabetes·N Maneka G De SilvaDeborah A Lawlor

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