Serum albumin and antibodies in the diagnosis of thyroid cancer

The Journal of Clinical Endocrinology and Metabolism
L J DeGrootH Rochman


Anti-thyroglobulin antibodies, anti-thyroid microsomal antibodies, serum thyroglobulin, and carcinoembryonic antigen were assayed in sera of patients with a history of thyroid irradiation and in patients with thyroid cancer. In irradiated patients, the frequency of positive results for each test was increased above the frequency found in a control population, with a significant increase at P less than .05 for TGHA and TG levels. However, the tests (with the exception of serum thyroglobulin) did not clearly segregate irradiated patients with benign or malignant lesions from those with no clinically detectable abnormalities. Elevations of serum thyroglobulin above 300 ng/ml were found only in patients with thyroid cancer, but in these patients the diagnosis was usually clinically obvious.


Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·L J DeGroot
Jul 17, 2001·International Journal of Andrology·R R MaranM M Aruldhas
Aug 9, 1979·The New England Journal of Medicine·A J Van HerleJ Dumont
Jan 27, 1999·Thyroid : Official Journal of the American Thyroid Association·J TakamatsuT Hosoya
Sep 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A SpencerJ T Nicoloff
Jan 1, 1981·Journal of Endocrinological Investigation·A J Van HerleJ Dumont
Jul 27, 2006·The Journal of Clinical Endocrinology and Metabolism·K BoelaertJ A Franklyn
Jan 1, 1994·Autoimmunity·P CaturegliN R Rose
Jul 1, 1981·Postgraduate Medicine·E L Mazzaferri
Jan 1, 1981·Journal of Surgical Oncology·I B Rosen

Related Concepts

Tumor Antigens
Carcinoembryonic Antigen
Radiation-Induced Cancer
Thyroid Gland
Thyroid Gland Follicular Adenoma

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.