Serum albumin and antibodies in the diagnosis of thyroid cancer

The Journal of Clinical Endocrinology and Metabolism
L J DeGrootH Rochman

Abstract

Anti-thyroglobulin antibodies, anti-thyroid microsomal antibodies, serum thyroglobulin, and carcinoembryonic antigen were assayed in sera of patients with a history of thyroid irradiation and in patients with thyroid cancer. In irradiated patients, the frequency of positive results for each test was increased above the frequency found in a control population, with a significant increase at P less than .05 for TGHA and TG levels. However, the tests (with the exception of serum thyroglobulin) did not clearly segregate irradiated patients with benign or malignant lesions from those with no clinically detectable abnormalities. Elevations of serum thyroglobulin above 300 ng/ml were found only in patients with thyroid cancer, but in these patients the diagnosis was usually clinically obvious.

Citations

Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·L J DeGroot
Jul 17, 2001·International Journal of Andrology·R R MaranM M Aruldhas
Aug 9, 1979·The New England Journal of Medicine·A J Van HerleJ Dumont
Jan 27, 1999·Thyroid : Official Journal of the American Thyroid Association·J TakamatsuT Hosoya
Sep 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A SpencerJ T Nicoloff
Jan 1, 1981·Journal of Endocrinological Investigation·A J Van HerleJ Dumont
Jul 27, 2006·The Journal of Clinical Endocrinology and Metabolism·K BoelaertJ A Franklyn
Jan 1, 1994·Autoimmunity·P CaturegliN R Rose
Jul 1, 1981·Postgraduate Medicine·E L Mazzaferri
Jan 1, 1981·Journal of Surgical Oncology·I B Rosen

Related Concepts

Tumor Antigens
Carcinoembryonic Antigen
Microsomes
Radiation-Induced Cancer
Thyroglobulin
Thyroid Gland
Thyroid Gland Follicular Adenoma

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