Serum albumin and beta-amyloid deposition in the human brain.

Neurology
Jee Wook KimKBASE Research Group

Abstract

To investigate the relationships of serum albumin with in vivo Alzheimer disease (AD) pathologies, including cerebral β-amyloid (Aβ) protein deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMH), in the human brain. A total of 396 older adults without dementia underwent comprehensive clinical assessments, measurement of serum albumin level, and multimodal brain imaging, including [11C] Pittsburgh compound B-PET, 18F-fluorodeoxyglucose-PET, and MRI. Serum albumin was categorized as follows: <4.4 g/dL (low albumin), 4.4 to 4.5 g/dL (middle albumin), and >4.5 g/dL (high albumin; used as a reference category). Aβ positivity, AD-signature region cerebral glucose metabolism (AD-CM), AD-signature region cortical thickness (AD-CT), and WMH volume were used as outcome measures. Serum albumin level (as a continuous variable) was inversely associated with Aβ deposition and Aβ positivity. The low albumin group showed a significantly higher Aβ positivity rate compared to the high albumin group (odds ratio 3.40, 95% confidence interval 1.67-6.92, p = 0.001), while the middle albumin group showed no difference (odds ratio 1.74, 95% confidence interval 0.80-3.77, p = 0.162). Neither serum album...Continue Reading

References

May 1, 1975·Journal of Gerontology·D P MisraG E Staddon
May 11, 1991·Lancet·P R WenhamG Blandell
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Feb 1, 1973·Age and Ageing·R G LeaskF I Caird
Jan 1, 1994·Advances in Protein Chemistry·D C Carter, J X Ho
Dec 20, 1996·The Journal of Biological Chemistry·A L BiereD J Selkoe
Feb 19, 2000·Biochemical and Biophysical Research Communications·Y M KuoA E Roher
Jan 31, 2004·Journal of the International Neuropsychological Society : JINS·Dong Y LeeJong I Woo
May 14, 2004·Journal of Neurochemistry·Berislav V Zlokovic
Jul 2, 2004·The New England Journal of Medicine·Jeffrey L Cummings
Apr 27, 2005·Neurology·M G DikP Eikelenboom
May 4, 2005·The American Journal of Medicine·Giuseppe ZuccalàRoberto Bernabei
Mar 15, 2006·International Journal of Geriatric Psychiatry·Tae-Suk KimChang-Uk Lee
Jan 5, 2008·American Journal of Alzheimer's Disease and Other Dementias·Eliyahu Hayim MizrahiAbraham Adunsky
Dec 5, 2008·Journal of the American Geriatrics Society·Tze-Pin NgKeng-Bee Yap
Dec 17, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel E WeinerMark J Sarnak
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanRichard J Caselli
Nov 4, 2009·Biophysical Journal·Julijana MilojevicGiuseppe Melacini
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Mar 9, 2010·Current Alzheimer Research·D J LlewellynI A Lang
Feb 20, 2014·Stroke; a Journal of Cerebral Circulation·Wei-Hai XuRalph L Sacco
Jun 9, 2016·PloS One·Asami OtaUNKNOWN Japan Gerontological Evaluation Study (JAGES) group
Jan 9, 2019·Frontiers in Aging Neuroscience·Sarah WestwoodSimon Lovestone
Jan 23, 2019·Brain : a Journal of Neurology·Jong-Chan ParkInhee Mook-Jung
Mar 13, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Mercè BoadaAntonio Páez

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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS Statistics

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