PMID: 3214125Jul 1, 1988Paper

Serum albumin by dye-binding: bromocresol green or bromocresol purple? The case for conservatism

Annals of Clinical Biochemistry
J M McGinlay, R B Payne

Abstract

Pooled patient's serum selected to have a wide range of albumin concentrations was analysed for albumin by bromocresol green with both long and short incubation times and also by bromocresol purple. Total protein, colloid osmotic pressure, calcium and magnesium were also measured. There were strong linear correlations between albumin measured by the three methods. Albumin values by bromocresol green with a short incubation time (1.5 min) averaged 5 g/L higher than those by bromocresol purple at all albumin concentrations. Colloid osmotic pressure correlated less strongly with total protein and with albumin by bromocresol purple than with albumin by the two bromocresol green methods. There were no significant differences between the correlation coefficients of calcium or magnesium with total protein and with albumin measured by the three methods. Bromocresol purple has no advantage over bromocresol green with a short incubation time for the clinical purposes for which albumin is measured: to detect abnormality, monitor change, predict colloid osmotic pressure and adjust calcium and magnesium for abnormal protein concentrations.

References

Mar 1, 1987·Journal of Clinical Pathology·I R Gunn, E Burns
Feb 28, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·G A Maguire, C P Price
Nov 1, 1985·Annals of Clinical Biochemistry·P G Hill
Jul 1, 1985·Annals of Clinical Biochemistry·R B Payne
May 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Webster
Aug 1, 1983·American Journal of Clinical Pathology·R E MullinsR H Gadsden

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Citations

Sep 29, 2001·Kidney International·K L JohansenP Painter
Nov 1, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Patricia L GordonKirsten L Johansen
Aug 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Berthil H C M T Prinsen, Monique G M de Sain-van der Velden
Jun 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kamyar Kalantar-ZadehSander Greenland
Dec 27, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Hitomi IwasakiTeruyuki Komatsu
Aug 31, 2004·Veterinary Clinical Pathology·Younès ChorfiArmand Tremblay
Aug 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C M ClaseD N Churchill
Feb 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T Doumas, T Peters

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