Serum albumin is an early predictor of complications after liver surgery

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Ismail LabgaaMartin Hubner

Abstract

The morbidity associated with liver surgery remained substantially high despite considerable surgical and anesthetic improvements. The unmet need of accurate biomarkers to predict postoperative complications is widely accepted. This pilot study aimed to assess serum albumin as a surrogate marker of surgical stress and to test its potential predictive role for postoperative complications. This retrospective pilot study included 106 patients who underwent liver surgery between 2010 and 2014. Serum albumin levels were measured pre- and post-operatively. Maximal albumin decrease (AlbΔmin) was correlated with complications. Serum albumin rapidly dropped after surgery. AlbΔmin was significantly increased in patients with complications (14.5±6.0g/L vs. 10.3±7.2, p=0.009). On multivariate analysis, ASA III/IV (p=0.016) and AlbΔmin (p=0.037) were the only predictors of overall complications. Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations.

References

Jul 1, 2006·Current Opinion in Critical Care·Benjamin A Kohl, Clifford S Deutschman
Aug 6, 2015·World Journal of Surgery·Styliani MantziariMarkus Schäfer

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Citations

Aug 23, 2017·Journal of Clinical Monitoring and Computing·Clemence PetitLouis Atallah
Aug 11, 2017·Diseases of the Colon and Rectum·Ismail LabgaaMartin Hübner
Feb 23, 2017·World Journal of Gastroenterology : WJG·Gaëtan-Romain JoliatNermin Halkic
Jan 15, 2019·World Journal of Clinical Cases·Narongsak RungsakulkijSuraida Aeesoa
Jan 25, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gregoire LongchampGaëtan-Romain Joliat
Nov 5, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ismail LabgaaMartin Hübner

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