Serum albumin, retinol-binding protein, thyroxin-binding prealbumin and acute phase reactants as indicators of undernutrition in children with undue susceptibility to acute infections

Acta paediatrica Scandinavica
M BondestamM Gebre-Medhin

Abstract

This study was conducted in order to test the usefulness of measuring the concentrations of selected serum proteins and acute phase reactants in assessing the nutritional status of children with undue susceptibility to acute infections. The concentrations of serum proteins were determined by an immunodiffusion technique in 28 children with undue susceptibility to infections and were compared with those in healthy children. The patients were grouped according to the clinical pattern, i.e. into children with mainly upper respiratory tract infections, with frequent middle ear infections and with lower respiratory tract infections. The total group and all three subgroups of patients had not only significantly lower (p less than 0.001 or p less than 0.01) mean serum levels of albumin and retinol-binding protein, but also of the acute phase reactants alpha 2-macroglobulin and ceruloplasmin (p less than 0.01) than the controls. No differences were observed between the patients and the controls in respect of the acute phase reactant orosomucoid. This study indicates that the concentrations of albumin and RBP along with selected acute phase reactants are rapidly influenced by altered nutritional status in children with undue susceptibil...Continue Reading

References

Jul 1, 1979·The Journal of Pediatrics·J D Lloyd-Still
May 1, 1975·Metabolism: Clinical and Experimental·Y IngenbleekM De Visscher
Jul 15, 1972·Lancet·Y IngenbleekP De Nayer
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Oct 1, 1965·The Journal of Clinical Investigation·E L SocolowS H Ingbar

Citations

Nov 20, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·W H Oldewage-TheronC S Venter
Jun 30, 2015·Nature Genetics·Regie Lyn P Santos-CortezSuzanne M Leal
Sep 2, 2009·Neonatal Network : NN·Patricia Nash
Jul 6, 2000·Revista do Hospital das Clínicas·A F DelgadoF R Carrazza
May 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·P DrottM Gebre-Medhin

Related Concepts

Acute Disease
Acute-Phase Proteins
Bacterial Infections
Serum Proteins
Disease Susceptibility
Malnutrition
Relapse
Retinoid Binding Protein, F-Type
Plasma Albumin
Thyroxine-Binding Proteins

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