Serum alkaline phosphatase and 30-day mortality after surgery for spinal metastatic disease

Journal of Neuro-oncology
Aditya V KarhadeJoseph H Schwab

Abstract

Elevated serum alkaline phosphatase has been previously studied as a biomarker for progression of metastatic disease and implicated in adverse skeletal events and worsened survival. The purpose of this study was to determine if serum alkaline phosphatase was a predictor of short-term mortality of patients undergoing surgery for spinal metastatic disease. The American College of Surgeons National Surgical Quality Improvement Program was queried for patients undergoing spinal surgery for metastatic disease. Bivariate and multivariable analyses was undertaken to determine the relationship between serum alkaline phosphatase and 30-day mortality. For the 1788 patients undergoing operative intervention for spinal metastatic disease between 2009 and 2016 the 30-day mortality was 8.49% (n = 151). In patients who survived beyond 30-days after surgery, n = 1627 (91.5%) the median [interquartile range] serum alkaline phosphatase levels were 126.4 [75-138], whereas in patients who had 30-day mortality, the serum alkaline phosphatase levels were 179.8 [114-187]. The optimal cut-off for alkaline phosphatase was determined to be 113 IU/L. On multivariable analysis, elevated serum alkaline phosphatase levels were associated with 30-day mortali...Continue Reading

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Citations

Feb 23, 2019·British Journal of Cancer·Aditya V KarhadeJoseph H Schwab
Sep 15, 2020·Journal of Orthopaedics·Quirina C B S ThioJoseph H Schwab

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