Abstract
Recent studies have identified macrophage-mediated injury as an important component in the development of diabetic nephropathy. The aim of this study was to investigate the correlations between serum allograft inflammatory factor-1 (AIF-1) concentration, which is a marker of activated macrophages, and diabetic nephropathy. Serum AIF-1 concentrations were measured in 284 patients with type 2 diabetes. We evaluated relationships of serum AIF-1 concentrations to degree of urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in univariate and multivariate linear regression analyses. Serum AIF-1 concentrations positively correlated with logarithm of UAE (r=0.260, P<0.0001), whereas serum AIF-1 concentrations inversely correlated with eGFR (r=-0.312, P<0.0001). Mean serum AIF-1 concentration was higher in patients with macroalbuminuria than that in patients with normoalbuminuria (P=0.0001) or that in patients with microalbuminuria (P=0.0093). In multivariate linear regression analyses, serum AIF-1 concentrations were independently correlated with logarithm of UAE (β=0.213, P=0.0120) and with eGFR (β=-0.286, P=0.0011). Serum AIF-1 concentration correlated with albuminuria and eGFR in patients with type 2 diab...Continue Reading
References
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T FurutaK Yoshinaga
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z W ChenS Efendic
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Oct 28, 2004·The Journal of Clinical Endocrinology and Metabolism·Hisato KoshibaHideo Honjo
May 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuichi KikuchiSoichiro Miura
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Annal D MelethEmily Y Chew
Mar 1, 2006·Journal of Diabetes and Its Complications·Kohzo TakebayashiToshihiko Inukai
Oct 13, 2006·Kidney International·Y TsubataF Gejyo
Jan 29, 2008·Current Diabetes Reviews·Alessia FornoniOliver Lenz
Jan 29, 2008·Current Diabetes Reviews·Martha Rodríguez-Morán, Fernando Guerrero-Romero
Mar 26, 2008·Investigative Ophthalmology & Visual Science·Mingyuan WuTimothy J Lyons
Feb 4, 2010·Journal of Atherosclerosis and Thrombosis·Birgit Gustafson
Apr 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru HorioSeiichi Matsuo
Apr 22, 2011·Kidney International·Sufyan G SayyedHans-Joachim Anders
Citations
Nov 26, 2013·BMC Endocrine Disorders·Silvia Lorente-CebriánIngrid Dahlman
Sep 28, 2018·Personalized Medicine·Jin DengWeiming Zeng
May 12, 2018·International Journal of Molecular Medicine·Yushu LiLirong Hao
Sep 24, 2019·Molecular Medicine Reports·Xueying YuanLirong Hao
Nov 6, 2018·Cancer Cell International·Ferial Amira SlimFrancine Durocher
May 22, 2020·JCI Insight·Diana M ElizondoMichael W Lipscomb
Dec 13, 2019·Immunology Letters·Mateusz SikoraAndrzej Pawlik