Serum allograft inflammatory factor-1 is a novel marker for diabetic nephropathy

Diabetes Research and Clinical Practice
Michiaki FukuiNaoto Nakamura

Abstract

Recent studies have identified macrophage-mediated injury as an important component in the development of diabetic nephropathy. The aim of this study was to investigate the correlations between serum allograft inflammatory factor-1 (AIF-1) concentration, which is a marker of activated macrophages, and diabetic nephropathy. Serum AIF-1 concentrations were measured in 284 patients with type 2 diabetes. We evaluated relationships of serum AIF-1 concentrations to degree of urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in univariate and multivariate linear regression analyses. Serum AIF-1 concentrations positively correlated with logarithm of UAE (r=0.260, P<0.0001), whereas serum AIF-1 concentrations inversely correlated with eGFR (r=-0.312, P<0.0001). Mean serum AIF-1 concentration was higher in patients with macroalbuminuria than that in patients with normoalbuminuria (P=0.0001) or that in patients with microalbuminuria (P=0.0093). In multivariate linear regression analyses, serum AIF-1 concentrations were independently correlated with logarithm of UAE (β=0.213, P=0.0120) and with eGFR (β=-0.286, P=0.0011). Serum AIF-1 concentration correlated with albuminuria and eGFR in patients with type 2 diab...Continue Reading

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Citations

Nov 26, 2013·BMC Endocrine Disorders·Silvia Lorente-CebriánIngrid Dahlman
Sep 28, 2018·Personalized Medicine·Jin DengWeiming Zeng
Sep 24, 2019·Molecular Medicine Reports·Xueying YuanLirong Hao
Nov 6, 2018·Cancer Cell International·Ferial Amira SlimFrancine Durocher
May 22, 2020·JCI Insight·Diana M ElizondoMichael W Lipscomb
Dec 13, 2019·Immunology Letters·Mateusz SikoraAndrzej Pawlik

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