PMID: 7516751Feb 1, 1994Paper

Serum alpha 1-antitrypsin and alpha 2-macroglobulin in Alzheimer's and Binswanger's disease

The Clinical Investigator
T Wetterling, K F Tegtmeyer

Abstract

The deposition of beta A4-amyloid in senile plaques and small cerebral vessels is one of the pathological hallmarks of Alzheimer's disease. Recent data suggest that protease inhibitors such as alpha 2-macroglobulin may be involved in the process of forming beta A4 amyloid deposits. Compared to 34 persons without neurological diseases, the serum content of alpha 1-antitrypsin was increased in 16 patients with Alzheimer's disease and 15 with Binswanger's disease. In the latter alpha 2-macroglobulin was also elevated in serum. Our results show no evidence of a blood-borne origin of the protein or peptid deposited in the walls of small vessels in Alzheimer's or Binswanger's disease. Nevertheless, the elevated proteinase inhibitor concentrations may play a role in the pathogenesis of these diseases.

Citations

Oct 3, 2012·PloS One·Steven John KiddleUNKNOWN Alzheimers Disease Neuroimaging Initiative
Dec 3, 2016·Journal of Alzheimer's Disease : JAD·Liming ShenJiazuan Ni
Apr 6, 2004·Journal of Clinical Laboratory Analysis·Robert F RitchieWendy Y Craig
Oct 1, 1998·Arquivos de neuro-psiquiatria·C André

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