Serum alpha-1-antitrypsin concentration during normal and diabetic pregnancy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Barbara Lisowska-MyjakJan Pachecka

Abstract

The aim of this study was a comparison of serum alpha-1-antitrypsin (AAT) concentration in the course of normal and diabetic pregnancy. Serum AAT concentration was determined on NOR-Partigen plates (Behring Diagnostics GmbH, Marburg). The studied material included healthy women without pregnancy (n=14), healthy pregnant women in the first trimester (n=12), second trimester (n=15), third trimester (n=15), and 16 pregnant women with type-1 diabetes mellitus studied prospectively in successive stages of pregnancy. In the first trimester of normal pregnancy, a significant increase of serum AAT concentration was observed in comparison with healthy women without pregnancy (P<0.01). In all stages of pregnancy with type-1 diabetes mellitus, a higher increase of AAT concentration was found as compared with healthy pregnant women (P<0.0001), especially in third trimester. There was no correlation shown between concentration of AAT and fructosamine in the serum of healthy and diabetic pregnant women (P>0.05). During normal and diabetic pregnancy, an increase of serum AAT concentration occurred with the regression lines exhibiting a different slopes. The highest AAT concentration was observed in third trimester of diabetic pregnancy. Incre...Continue Reading

References

Oct 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·P HallR C Roberts
Sep 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C H NielsenJ G Westergaard
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F K Askari
Sep 1, 1995·American Journal of Perinatology·J A KullerC L Bristow
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·J M MorrisC W Redman

❮ Previous
Next ❯

Citations

Feb 22, 2002·Prenatal Diagnosis
Dec 12, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Barbara Lisowska-Myjak, Jan Pachecka
Apr 7, 2009·Diabetes Research and Clinical Practice·Minoo YaghmaeiSaeid Ghavami
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara Lisowska-Myjak
Nov 14, 2014·Revue des maladies respiratoires·M BalduyckB Maitre
May 9, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamar MadarEli C Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.