PMID: 70265Aug 1, 1977Paper

Serum alpha-fetoprotein levels after hepatic artery ligation and postoperative chemotherapy: correlation with clinical status in patients with hepatocellular carcinoma

Cancer
N NagasueM Saku

Abstract

Eight patients with hepatocellular carcinoma and positive serum alpha-fetoprotein (AFP) levels were treated by hepatic artery legation and postoperative chemotherapy. Three patterns of clinical response were discerned. First, a marked decrease in AFP levels was found in five patients following the treatment. Three of these patients are alive, all with lowered or normal serum AFP levels at 20, 22, and 60 weeks after operation. Second, two patients displayed only a transient decrease in AFP levels followed by a gradual increase. Third, there was a continuous increase in AFP levels in one patient who showed no clinical improvement. The serum AFP levels in each case appeared to correlate with the prognosis of these patients. Thus, serial measurements of AFP levels may provide an index to assess the clinical result of hepatic artery ligation in patients affected with hepatoma.

Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·Y KatagiriT Kawai
Apr 1, 1980·Digestive Diseases and Sciences·N NagasueR Kanashima
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A MuraokaJ Sato
Sep 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·P K BuamahA W Skillen
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Dec 1, 1983·International Journal of Radiation Oncology, Biology, Physics·M A Friedman
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Jun 2, 2020·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Nov 22, 2018·Clinical and Experimental Medicine·Nabil M Abdel-Hamid, Amer Hasan Abdullah

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