PMID: 6162267Jan 1, 1980Paper

Serum alpha-fetoprotein-positive gastric carcinoid with liver metastasis

Virchows Archiv. A, Pathological Anatomy and Histology
H MoriR Fukunishi

Abstract

The patient was a 60-year-old Japanese male. He complained of epigastralgia and right chest pain of 4 month's duration, and general malaise, nausea and vomiting of 2 month's duration. Physical examination revealed on the right third rib a tender mass with a diameter of 2 cm and hepatomegaly with a multi-nodular surface and red palms. There were no signs of carcinoid syndrome, such as cutaneous flushing. Laboratory examinations disclosed certain biochemical alterations; alkaline phosphatase 810 IU/l, gamma-glutamyl transpeptidase (gamma-GTP) 2090 IU/l, carcinoembryonic antigen (CEA) 23.5 ng/ml and alpha-fetoprotein (AFP) 6,800 ng/ml. Both HBs-Ag and HBs-Ab were negative. The patient died in a uremic state, with rapid increases of jaundice and ascites. Autopsy revealed gastric carcinoid with extensive metastases to the liver and the bone marrow. Tumor cells showed argyrophilia but not argentaffinity. Immunofluorescence specific for AFP was positive in the hepatocytes, particularly those adjacent to the metastatic tumor cells but not in the tumor cells, either primary or secondary. 79 cases reported in Japan of serum AFP-positive malignant tumor other than hepatocellular carcinoma and certain other malignancies of germ cell origin...Continue Reading

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Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·A TiltmanW Levin
Mar 1, 1985·Acta Pathologica Japonica·T MotoyamaH Watanabe
Dec 1, 1989·Current Problems in Surgery·J M Feldman
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thein H OoHani Hassoun

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