Serum amino acid metabolic profiles of ankylosing spondylitis by targeted metabolomics analysis.

Clinical Rheumatology
Yong ZhouHao Chen

Abstract

Ankylosing spondylitis (AS) is a common chronic inflammatory arthritis, causing lasting back pain with progressive loss of spinal mobility. However, the exact pathogenesis of AS remains unclear. We aim to use the metabolomics analysis to characterize the metabolic profile of AS, in order to better understand the pathogenesis of AS and monitor disease activity and progression. The ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-TQ-MS) was used for investigating the serum amino acid metabolomic profiling of 30 AS patients, in comparison with 32 rheumatoid arthritis (RA) patients and 30 healthy controls, combined with multivariate statistical analysis. Metabolite association analysis with disease activity was performed using generalized linear regression. The metabolic pathway analysis for the important metabolites was performed using MetPA and the metabolic network was constructed. A total of 29 amino acids and biogenic amines were detected in all participants by UPLC-TQ-MS. It showed significant amino acid differences between the AS/RA patients and control subjects. Additionally, 4-hydroxy-L-proline, alanine, γ-aminobutyric acid, glutamine, and taurine were identified as candidate markers s...Continue Reading

References

Mar 31, 2004·Annals of the Rheumatic Diseases·M C W CreemersP L C M van Riel
Dec 5, 2006·Disease-a-month : DM·Gina Gill Glass
Aug 15, 2009·Zeitschrift für Rheumatologie·M RudwaleitUNKNOWN Assessment of SpondyloArthritis international Society
Apr 15, 2010·Annals of the Rheumatic Diseases·Guangju ZhaiTim D Spector
Oct 15, 2011·Molecular & Cellular Proteomics : MCP·Roman FischerBenedikt M Kessler
Jul 20, 2012·Amino Acids·Janusz Marcinkiewicz, Ewa Kontny
Jul 4, 2013·Journal of Proteome Research·Miao JiangAiping Lu
Jan 27, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Zaneta SmolenskaZbigniew Zdrojewski
Apr 15, 2016·Analytical and Bioanalytical Chemistry·Gang YangJian Zhang
Aug 24, 2016·BMC Musculoskeletal Disorders·Zuzana TatarMartin Soubrier
Mar 23, 2017·International Journal of Rheumatic Diseases·Min HeJan van der Greef
Apr 26, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kaidi ZhengXinyu Yang
Apr 28, 2017·Nature Reviews. Rheumatology·Vidya RanganathanNigil Haroon
Jul 18, 2017·Rheumatic Diseases Clinics of North America·Aimee Hanson, Matthew A Brown
Nov 23, 2017·Environmental Health and Preventive Medicine·M H MahbubTsuyoshi Tanabe
Mar 20, 2018·Biochemical and Biophysical Research Communications·Alyssa K CarlsonRonald K June
Apr 10, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rui ChenXi Zhang
May 23, 2018·Journal of Immunology Research·Maria Cristina Moran-MoguelMaria G Zavala-Cerna
Aug 11, 2018·Journal of Proteome Research·Avinash JainRamnath Misra
Dec 28, 2018·Arthritis Research & Therapy·Lucy LawHelena Forsblad-d'Elia
May 31, 2019·Rheumatology and Therapy·Johannes C NossentGunnstein Bakland
Jul 31, 2019·BioMed Research International·Chong ChenJianxiong Shen

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