Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A C FarrowNaomi Winick

Abstract

The clinical significance of methotrexate (MTX)-induced hepatic toxicity in children with acute lymphoblastic leukemia (ALL) is poorly defined. Therefore, we conducted a study to determine whether intensive MTX therapy could be safely delivered despite isolated serum ALT elevations in children with ALL. A total of 243 children with B-precursor ALL were treated with extended pulses of oral divided-dose MTX (dMTX). Serum ALT levels were measured approximately every 7 weeks during therapy, as well as after its cessation. By protocol design, treatment was continued without modification in the presence of ALT elevations if there was no other evidence of liver dysfunction. Of 239 assessable patients, 159 (66.5%) had an ALT level > or = 180 IU/L during therapy and 28 patients (17.6%) had one or more values > or = 720 IU/L. After the completion of therapy, only 17 of 104 assessable patients have had one or more elevated ALT value. Eight of these 17 patients (47%) are hepatitis C virus (HCV)-seropositive. The remaining nine children had subsequent normal or near normal ALT values, and none have clinical evidence of liver disease. Our data show that MTX can be safely delivered without dose modification in patients with isolated ALT eleva...Continue Reading

Citations

Jun 21, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Elena J Ladas, Kara M Kelly
Jun 7, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lydia TchambazStephan Krähenbühl
Jun 23, 2009·British Journal of Haematology·Kjeld Schmiegelow
Mar 15, 2011·British Journal of Clinical Pharmacology·Tiphaine Adam de BeaumaisEvelyne Jacqz-Aigrain
Aug 15, 2012·Pediatric Hematology and Oncology·Mojeb Mohammed SaifManal H El-Sayed
Jan 7, 2017·Journal of Pediatric Hematology/oncology·Maria S EbbesenKjeld Schmiegelow
Jun 18, 2014·Journal of Pediatric Hematology/oncology·Kjeld SchmiegelowJacob Nersting
Sep 5, 2007·Cancer Chemotherapy and Pharmacology·Peter D ColeBarton A Kamen

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