Serum amyloid a, a potential biomarker both in serum and tissue, correlates with ovarian cancer progression.

Journal of Ovarian Research
Ze LiLi Ren

Abstract

Ovarian cancer is the most fatal gynecologic malignancy worldwide due to its vagueness, delay in diagnosis, recurrence, and drug resistance. Therefore, a new type of ovarian cancer treatment prediction biomarker is urgently needed to supplement existing tools. A total of 230 people participated in this study. Out of this figure, 100 participants were patients who underwent an ovarian tumor operation, another 100 participants were ovarian benign patients, and the remaining 30 participants were healthy women. Cancer (experimental) group were 100 patients who underwent ovarian tumor operation, while the control groups were 130 participants consisting of 100 ovarian benign patients and 30 healthy women. Levels of SAA, carbohydrate antigen-125 (CA-125), and human epididymis protein 4 (HE4) were assessed using standard laboratory protocols. A total of 5 ovarian cancer tissues and paracancerous tissues were collected and then stored at - 80 °C until the qRT-PCR assay was conducted. The ROC curve of SAA concentration in ovarian cancer was plotted to obtain the area under the curve AUC = 0.889, the cut-off value 17.05 mg/L, the sensitivity 78.4% and specificity 86.5%. Compared with pretreatment, the level of serum SAA decreased signific...Continue Reading

References

Jan 1, 1988·Methods in Enzymology·I Kushner
Jun 1, 1996·European Journal of Clinical Investigation·E Malle, F C De Beer
Jan 30, 2004·Cancer Cell·Robert F OzolsThomas C Hamilton
Aug 26, 2004·British Journal of Haematology·Pier Luigi TazzariAlberto M Martelli
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 26, 2006·Annals of Surgical Oncology·De-Chuan ChanJenn-Han Chen
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·E MalleA Kovacevic
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ReedUNKNOWN ESMO Guidelines Working Group
Aug 18, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Simcha Urieli-ShovalDiana Prus
Jan 1, 2007·Proteomics. Clinical Applications·Sergei A MoshkovskiiAlexander I Archakov
Dec 17, 2010·The Journal of Biological Chemistry·Jonathan L ColoffJeffrey C Rathmell
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Oct 16, 2012·Gynecologic Oncology·Karen K L ChanWalfrido W Sumpaico
Jan 23, 2014·Diagnostic Pathology·Yanjie RenShanling Liu
Mar 19, 2014·Molecular Immunology·Khoa D NguyenElizabeth D Mellins
May 16, 2014·The Journal of Veterinary Medical Science·Takashi TamamotoHajime Tsujimoto
Feb 6, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Gemma ShayBarbara Fingleton
Jan 21, 2016·Nature Reviews. Clinical Oncology·Steven Narod
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Farshid DayyaniMatthew Schlumbrecht
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 13, 2017·Veterinary Immunology and Immunopathology·Takashi TamamotoHajime Tsujimoto
Jan 11, 2018·International Journal of Nanomedicine·Guoying DengQian Wang

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Citations

May 1, 2021·International Journal of Molecular Sciences·Alexey P Galkin, Evgeniy I Sysoev
Aug 2, 2021·Experimental Cell Research·Daniel Wilhelm OlivierAnna-Mart Engelbrecht

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Methods Mentioned

BETA
protein assay

Software Mentioned

SPSS
GraphPad Prism
Oncomine

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