Serum amyloid a and C-reactive protein independently predict the recurrences of atrial fibrillation after cardioversion in patients with preserved left ventricular function

The Canadian Journal of Cardiology
Alessandra BarassiGian Vico Melzi D'eril

Abstract

Subclinical inflammation and atrial stretch have been recognized as important contributors to atrial fibrillation (AF) onset and perpetuation. The aim of the study was to compare the predictive role of serum inflammatory markers (serum amyloid A [SAA], and C-reactive protein [CRP]) and N-terminal pro brain natriuretic peptide (NT-proBNP) an indice of atrial strain in relation to subacute arrhythmic recurrence rate in patients with persistent AF and normal left ventricular ejection fraction (LVEF). We studied 57 patients with a mean LVEF of 58.7 ± 6%. NT-proBNP, SAA and CRP levels were determined few hours before electrical cardioversion and 3 weeks after cardioversion. Subacute AF recurrences were documented in 19 (33 %) patients. Whereas NT-proBNP levels did not predict arrhythmic outcome, higher SAA (> 6.16-6.19 mg/L) and CRP levels (> 2.99-3.10 mg/L) were significantly associated with AF recurrences (odds ratio [OR], 5.39; 95% confidence interval [CI], 1.59-18.26; P = 0.007 and OR, 14.93; 95% CI, 3.90-57.19; P < 0.001). Both SAA (OR, 18.29; 95% CI, 2.07-161.46; P = 0.009) and high sensitivity CRP (OR, 42.03; 95% CI, 4.83-365.45; P = 0.001) through the multivariate logistic regression analysis show an independent role in pred...Continue Reading

References

Feb 7, 2001·Circulation·M A AllessieA L Waldo
Jan 24, 2002·Nature·Stanley Nattel
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Sep 20, 2005·International Journal of Cardiology·Panagiotis KorantzopoulosKonstantinos Siogas
Jun 8, 2007·The New England Journal of Medicine·Helen J LachmannPhilip N Hawkins
Nov 3, 2010·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Jean D SipePer Westermark

❮ Previous
Next ❯

Citations

May 16, 2013·Scandinavian Journal of Immunology·K T LappegårdT E Mollnes
Nov 12, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Wei Ren ChenYun Dai Chen
Aug 13, 2014·Pacing and Clinical Electrophysiology : PACE·Theodoros ZografosDemosthenes Katritsis
May 12, 2015·Disease Markers·Alessandra BarassiMassimiliano Marco Corsi Romanelli
Feb 28, 2015·Journal of Periodontal & Implant Science·Carlos Martín Ardila, Isabel Cristina Guzmán
Jan 20, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Muhammad Ali AneesElsayed Z Soliman
Sep 7, 2017·Current Medicinal Chemistry·Evangelos OikonomouDimitris Tousoulis
Mar 3, 2020·Current Medicinal Chemistry·Homa NomaniAmir Hooshang Mohammadpour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Ying LuanYe Tian
© 2021 Meta ULC. All rights reserved