Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways

Immunology Letters
S SandriAna Campa

Abstract

Although the serum levels of SAA had been reported to be upregulated during inflammatory/infectious process, the role of this acute-phase protein has not been completely elucidated. In previous studies, we demonstrated that SAA stimulated the production of TNF-alpha, IL-1beta, IL-8, NO, and ROS by neutrophils and/or mononuclear cells. Herein we demonstrate that SAA induces the expression and release of CCL20 from cultured human blood mononuclear cells. We also focus on the signaling pathways triggered by SAA. In THP-1 cells SAA promotes phosphorylation of p38 and ERK1/2. Furthermore, the addition of SB203580 (p38 inhibitor) and PD98059 (ERK 1/2 inhibitor) inhibits the expression and release of CCL20 in mononuclear cells treated with SAA. Our results point to SAA as an important link of innate to adaptive immunity, once it might act on the recruitment of mononuclear cells.

References

Feb 1, 1994·Biochemical Society Transactions·J G Raynes
Oct 3, 1999·European Journal of Biochemistry·C M Uhlar, A S Whitehead
Dec 23, 1999·Current Opinion in Hematology·S Urieli-ShovalY Matzner
Aug 6, 2003·FEMS Immunology and Medical Microbiology·Elaine HatanakaAna Campa
Aug 24, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Orit GutfeldSimcha Urieli-Shoval
May 3, 2006·Biochimica Et Biophysica Acta·Takashi MiidaMasahiko Okada
Feb 7, 2008·Journal of Leukocyte Biology·Silvana SandriAna Campa

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Citations

Oct 12, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F B Filippin-MonteiroA Campa
Mar 28, 2013·Mediators of Inflammation·Franciele Hinterholz KnebelAna Campa
May 3, 2014·Journal of Atherosclerosis and Thrombosis·Si-Zhen TanChew-Kiat Heng
Apr 23, 2013·Inflammation·Edson Mendes de OliveiraFabíola Branco Filippin-Monteiro
Dec 22, 2015·Cellular & Molecular Immunology·Zhou ZhouBin Gao
Dec 24, 2010·Clinical and Experimental Immunology·E HatanakaA Campa
Apr 30, 2016·Diabetologia·Edson M de OliveiraAna Campa
May 30, 2017·Biochemical and Biophysical Research Communications·Shouda GaoLinchao Sang
Nov 22, 2018·American Journal of Reproductive Immunology : AJRI·Ya-Wei WangHao Ying

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