PMID: 7516407Jul 1, 1994Paper

Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes

The Journal of Experimental Medicine
R BadolatoJ J Oppenheim

Abstract

Serum amyloid A (SAA) is an acute phase protein that in the blood is bound to high density lipoproteins; SAA is secreted mainly by hepatocytes, and its concentration increases in the blood up to 1000 times during an inflammatory response. At present, its biological function is unclear. Since some forms of secondary amyloidosis are caused by deposition in tissues of peptides derived from the SAA and leukocytes seem to be involved in this process, we investigated the effect of human SAA on human monocytes and polymorphonuclear cells (PMN). When recombinant human SAA (rSAA) was used at concentrations corresponding to those found during the acute phase (> 0.8 microM), it induced directional migration of monocytes and polymorphonuclear leukocytes. Preincubation of rSAA with high density lipoproteins blocked this chemoattractant activity for both monocytes and PMN. rSAA also regulated the expression of the adhesion proteins CD11b and leukocyte cell adhesion molecule 1 and induced the adhesion of PMN and monocytes to umbilical cord vein endothelial cell monolayers. When subcutaneously injected into mice, rSAA recruited PMN and monocytes at the injection site. On the basis of these data, we suggest that SAA may participate in enhancing...Continue Reading

References

Oct 1, 1978·The Journal of Experimental Medicine·G LavieE C Franklin
Dec 1, 1992·Journal of Internal Medicine·M Skinner
Sep 1, 1991·Immunobiology·V Kolb-Bachofen
Jun 5, 1980·The New England Journal of Medicine·G G Glenner
Sep 1, 1980·The Journal of Experimental Medicine·L L BaussermanK P McAdam
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
Next ❯

Citations

Mar 27, 2012·Modern Rheumatology·Kenshi SatomuraKiyoshi Migita
Jun 16, 2012·Cancer Metastasis Reviews·Jonathan P Sleeman
Feb 4, 2006·Current Atherosclerosis Reports·Kevin D O'Brien, Alan Chait
Aug 15, 2013·Veterinary Immunology and Immunopathology·Takashi TamamotoHajime Tsujimoto
Jul 1, 1997·Veterinary Immunology and Immunopathology·C HulténG Marhaug
Nov 5, 1999·The Biochemical Journal·B M SchreiberJ D Sipe
Oct 28, 1998·Scandinavian Journal of Immunology·H PatelP Woo
Oct 3, 1999·European Journal of Biochemistry·C M Uhlar, A S Whitehead
Jan 16, 2010·The Journal of Biological Chemistry·Irina N BaranovaThomas L Eggerman
Feb 1, 2013·Journal of Occupational and Environmental Hygiene·Anna M HejlLuke P Naeher
Aug 1, 2007·The Journal of Experimental Medicine·Maren LuchtefeldBernhard Schieffer
Jan 10, 2001·Current Opinion in Rheumatology·G Cunnane
Jun 1, 1996·Journal of Clinical Gastroenterology·G EfstratiadisM Leontsini
Dec 23, 1999·Current Opinion in Hematology·S Urieli-ShovalY Matzner
Jul 8, 2011·Current Opinion in Lipidology·Victoria L KingLisa R Tannock
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J Y SongK W Lee
Feb 24, 2006·Infection and Immunity·Jiamao ZhengDavid E Kerr
Nov 28, 2006·Biochemistry. Biokhimii︠a︡·M A Vlasova, S A Moshkovskii
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Steven BozinovskiGary P Anderson
Jun 12, 2004·American Journal of Respiratory Cell and Molecular Biology·Quan ShaRobert P Schleimer
Jul 2, 2010·The Journal of Clinical Investigation·Pak Cheung NgTerence Chuen Wai Poon
Nov 4, 2000·Arthritis Research·R O'HaraB Bresnihan
Mar 17, 2009·Journal of Lipid Research·Tsuyoshi ChibaAlan Chait
Nov 25, 2005·Pediatric Research·Teicha C WilsonSuhas G Kallapur
Mar 17, 2009·Pediatric Research·Qing YangAshima Madan
Aug 18, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Simcha Urieli-ShovalDiana Prus

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.