Serum amyloid a protein as a predictor of cardiac rupture in acute myocardial infarction patients following primary coronary angioplasty

Circulation Journal : Official Journal of the Japanese Circulation Society
Toshiro KatayamaKatsusuke Yano

Abstract

The predictors of cardiac rupture (CR) in patients with acute myocardial infarction (AMI) treated with successful primary coronary angioplasty have not been identified. Of 433 consecutive AMI subjects who underwent reperfusion by primary coronary angioplasty within 24 h of onset, CR occurred in 11 (2.5%), free wall rupture in 9, and ventricular septal perforation in 2. Rates of females, diabetes mellitus and anterior infarction were higher in the group of CR patients than in the others (p < 0.05). There were no significant differences between the 2 groups in terms of left ventricular (LV) function soon after recanalization, such as LV ejection fraction, regional wall motion, or end-diastolic volume index. Plasma levels of both high-sensitivity C-reactive protein (hsCRP) and serum amyloid-A protein (SAA) were significantly higher in the CR patients than in the others (hsCRP: 6.7 +/- 6.7 mg/dl vs 3.3 +/- 3.8 mg/dl, p = 0.007; SAA: 699 +/- 812 microg/dl vs 208 +/- 273 microg/dl, p < 0.0001). Multivariate analysis identified SAA as an independent predictor of CR (risk ratio: 8.8, 95% confidence interval: 1.7-25.6, p < 0.05). Conclusions In patients with AMI treated with primary coronary angioplasty, inflammation may be closely rela...Continue Reading

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Citations

Jul 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasushi InoTakashi Akasaka
Oct 6, 2010·The American Journal of Cardiology·Abel E MoreyraUNKNOWN MIDAS Study Group (MIDAS 13)
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Jan 21, 2021·Texas Heart Institute Journal·Stefano PidelloMassimo Boffini
Dec 1, 2020·Current Problems in Cardiology·J A Reyes-Retana, L C Duque-Ossa

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