PMID: 7540381Mar 1, 1995Paper

Serum amyloid A protein in patients with acute myocardial infarction

Annals of Clinical Biochemistry
M T CaslS Kranjcević

Abstract

The concentrations of four acute phase proteins were measured in sera of 40 patients with acute myocardial infarction (AMI) to evaluate their behaviour from day-to-day and to find out if they can serve for early prediction of postinfarction complications and mortality rate. Peak levels of serum amyloid A protein (SAA) were increased up to 5000-fold above the normal value and those of C-reactive protein (CRP) about 100-fold, 3 days after AMI. alpha 1-antichymotrypsin (ACT) and alpha 1-acid glycoprotein (AGP) peak levels were increased up to eightfold above their normal values. Patients who developed postinfarction complications had significantly higher SAA values on admission than those without complications (mean values of 379 and 45 mg/L, respectively; P < 0.0001). Using a level of 100 mg/L on admission as a reference value gave a reasonable sensitivity and predictive value for complications (73%) and a very good sensitivity (80%) for early prediction of fatal outcome. Patients with SAA values above this limit had double the risk of complications and four times the risk of a fatal outcome. The correlation with CRP values was lower than it was with SAA values (P = 0.028) using a level of 15 mg/L on admission as reference value ...Continue Reading

References

Oct 16, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·L L BaussermanP N Herbert
Jun 1, 1986·Journal of Clinical Pathology·R Shainkin-KestenbaumN Cristal
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jan 1, 1982·Annals of the New York Academy of Sciences·I Kushner
May 1, 1993·Annals of Clinical Biochemistry·M T CaslN Jagarinec

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Citations

Dec 13, 2005·International Journal of Cardiology·Andrew M WilsonAndrew J Boyle
Jul 15, 2009·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Cédric DelhayeJean-Marc Lablanche
Mar 10, 2010·The American Journal of Cardiology·Cedric DelhayeRon Waksman
Mar 2, 2006·American Journal of Nephrology·João Egidio RomãoHugo Abensur
Apr 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Oct 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Jan 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Mar 14, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Adrian J MolenaarKerst Stelwagen
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Ingrid GlurichErnesto De Nardin
Jan 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M T CaslD Simić
Dec 1, 2020·Current Problems in Cardiology·J A Reyes-Retana, L C Duque-Ossa
May 23, 2001·International Immunopharmacology·R NijmeijerC E Hack

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