Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome

Scientific Reports
Xian-Le BuYan-Jiang Wang

Abstract

A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in in vitro and animal studies but has not yet been proven in humans. Obstructive sleep apnea syndrome (OSAS) is a common disorder that is characterized by nocturnal intermittent hypoxaemia. This study sought to examine the association between the chronic intermittent hypoxia and Aβ in OSAS patients. Forty-five cognitively normal OSAS patients and forty-nine age- and gender-matched subjects diagnosed with simple snoring and not OSAS were included in the present study. Serum Aβ40, Aβ42, total tau and phosphorylated tau 181 (P-tau 181) levels were measured using ELISA kits. All subjects were evaluated with nighttime polysomnography and cognitive tests. Compared with the controls, the OSAS patients exhibited significantly higher serum Aβ40, Aβ42 and total Aβ levels, and each of these levels was positively correlated with the apnea-hypopnea index, the oxygen desaturation index, and the mean and lowest oxyhaemoglobin saturations in the OSAS patients. Moreover, the OSAS patients exhibited strikingly higher serum P-tau 181 levels, and these levels were positively correlated with serum Aβ levels. This study suggests that there is an association between chronic ...Continue Reading

References

Oct 1, 1985·The Journal of Cell Biology·L I BinderL I Rebhun
Feb 24, 2001·Aging : Clinical and Experimental Research·J P JanssensJ P Michel
Jan 23, 2002·European Neurology·Andreas BitschMarkus Otto
May 15, 2002·The Journal of Pediatrics·A J Wheeler, V van Someren
Dec 11, 2002·Journal of Neurochemistry·Nicola J WebsterPeter F T Vaughan
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·David Mullin
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·E Rand Sutherland, Richard J Martin
Nov 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiulian SunWeihong Song
May 15, 2007·The American Journal of Emergency Medicine·Cemil KavalciDilara Seckin
Dec 8, 2007·Neurobiology of Aging·Liang LiWeidong Le
Aug 12, 2008·Journal of Chemical Neuroanatomy·Panchanan MaitiGovindasami Ilavazhagan
Sep 18, 2008·Journal of the American Geriatrics Society·Sonia Ancoli-IsraelJose S Loredo
Feb 7, 2009·Journal of Neurochemistry·Michela GuglielmottoMassimo Tabaton
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Marcos A MarquesDavid G Cook
Oct 23, 2009·Annals of the New York Academy of Sciences·Chris PeersJohn P Boyle
Mar 5, 2011·Journal of Neuroscience Research·J Gregor SutcliffeBrian S Hilbush
Apr 15, 2011·Neurology·J LiUNKNOWN Chongqing Ageing Study Group
Jan 25, 2012·Traffic·Lawrence Rajendran, Wim Annaert
Mar 15, 2012·Molecular Neurobiology·Virve CavallucciFrancesco Cecconi
Feb 13, 2013·Neurotoxicity Research·Mak Adam Daulatzai
Mar 13, 2013·JAMA Neurology·Yo-El S JuDavid M Holtzman
May 21, 2013·FEBS Letters·Natalia N Nalivaeva, Anthony J Turner
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·Satomi ShiotaKazuhisa Takahashi
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Dec 25, 2013·Nature Reviews. Neurology·Yo-El S JuDavid M Holtzman
May 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Anne-Cécile TroussièreStéphanie Bombois
Jul 6, 2014·Neuro-degenerative Diseases·Chang-E ZhangGongping Liu
Sep 11, 2014·Annals of Neurology·Kaleigh Filisa RobertsRandall J Bateman
Oct 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Junyun HeWeihong Pan
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Weihong Pan, Abba J Kastin
Apr 17, 2015·Neurology·Ricardo S OsorioUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Citations

Jan 15, 2017·Chest·Jagan A Pillai, James B Leverenz
Dec 28, 2017·Journal of Alzheimer's Disease : JAD·Dong-Wan ChenChang-Yue Gao
Sep 30, 2017·Nature Reviews. Neurology·Jun WangYan-Jiang Wang
Sep 6, 2019·PloS One·Sylwia Przybylska-KućJerzy Mosiewicz
May 6, 2020·Sleep·Aditya AmbatiShahrad Taheri
May 28, 2017·Journal of Alzheimer's Disease : JAD·Arthur Cassa MacedoNaji Tabet
Jun 2, 2017·American Journal of Respiratory and Critical Care Medicine·Ivana Rosenzweig, Mary J Morrell
Apr 26, 2019·Annals of Clinical and Translational Neurology·Hao-Lun SunXian-Le Bu
May 28, 2020·Frontiers in Aging Neuroscience·Victoria M PakFannie Onen
Sep 5, 2019·Epilepsy & Behavior : E&B·Rani A SarkisGad Marshall
Oct 7, 2020·Sleep Medicine Reviews·Claudio LiguoriBiancamaria Guarnieri
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Luigi Ferini-StrambiMaria Salsone
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Salla Ylä-HerttualaEsa Mervaala
Mar 2, 2021·Neural Regeneration Research·Huang KuangShu-Long Yang
Apr 17, 2021·Ageing Research Reviews·Johannes BurtscherGrégoire P Millet
Oct 28, 2020·Science China. Life Sciences·Bin-Lu SunYan-Jiang Wang
Jul 3, 2021·Clinics in Geriatric Medicine·Arpan Patel, Derek J Chong
Aug 7, 2021·Nature and Science of Sleep·Xiangyi Gu, Junchao Zhu
Nov 10, 2018·ACS Chemical Neuroscience·Feng ZhangWeidong Le
Oct 8, 2021·Metabolic Brain Disease·Xiaoyin WangXunming Ji

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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