Serum and abomasal antibody response of sheep to infections with Haemonchus contortus

Veterinary Parasitology
J Charley-PoulainP Péry

Abstract

Serum and abomasal IgA, IgG and IgM antibody response against adult worm, L3 and egg antigens of Haemonchus contortus was monitored by the ELISA technique after one or two infections with this nematode. Following the first infection, antibody levels in serum did not change materially. After administration of a challenge dose of infective larvae, antibodies of the three immunoglobulin classes in infected animals rose slightly, but this rise appeared later than the fall in the faecal egg counts. In contrast, in abomasal mucosa, IgA anti-larval antibody levels, which did not increase materially after the primary infection, rose rapidly after a transient inhibition when sheep were challenged. A close temporal relationship was observed between the rise in local anti-worm IgA antibodies and the self-cure reaction, but antibody levels fell rapidly after worm diminution. The local antibody response was thus considered to be related to immunity of sheep to H. contortus.

References

Jun 22, 1978·Nature·D Wakelin
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Nov 10, 1973·The Veterinary Record·M Murray
Feb 1, 1973·Parasitology·E W Allonby, G M Urquhart

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Citations

Mar 1, 1996·International Journal for Parasitology·M T Gomez-MuñozJ M Alunda
Jul 1, 1995·International Journal for Parasitology·C TakátsW M Hendrikx
Sep 1, 1993·Veterinary Parasitology·M CuquerellaJ M Alunda
Nov 20, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M T Gómez-MuñozJ M Alunda
May 1, 2007·Pakistan Journal of Biological Sciences : PJBS·M M El-BahyH A Shalaby
Jul 1, 1994·Research in Veterinary Science·H D SchalligW M Hendrikx
Jul 25, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M T Gómez-MuñozM Cuquerella

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