Serum and adipose tissue as matrices for assessment of exposure to persistent organic pollutants in breast cancer patients

Environmental Research
F Artacho-CordónJ P Arrebola

Abstract

The aim of this study was to assess differences between two biological matrices (serum and breast adipose tissue) in the evaluation of persistent organic pollutant (POP) exposure in breast cancer patients. The study population consisted of 103 women undergoing surgery for newly diagnosed breast carcinoma in a public hospital in Granada, Southern Spain. Independent variables were gathered from questionnaires and clinical records. POP concentrations were quantified in breast adipose tissue and serum samples. Spearman correlation tests were performed between pairs of POP concentrations and stepwise multivariable linear regression analyses were conducted to assess predictors of concentrations in the two matrices. p,p'- Dichlorodiphenyldichloroethylene (p,p'-DDE) showed the the highest median concentration in both matrices (194.34 and 173.84 ng/g lipid in adipose tissue and serum, respectively). Median wet-basis adipose tissue:serum ratios ranged from 109.34 to 651.62, while lipid-basis ratios ranged from 0.88 to 4.34. In general, we found significant positive correlation coefficients between pairs of POPs in adipose tissue and in serum, which were always higher in adipose tissue. We found positive and statistically significant corr...Continue Reading

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Citations

Jan 7, 2016·Environment International·Ling LengNai-Jun Tang
Jul 21, 2016·Journal of Exposure Science & Environmental Epidemiology·Monika GubeAndré Esser
Sep 16, 2016·Environmental Science and Pollution Research International·Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
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Jun 15, 2017·Environmental Health : a Global Access Science Source·Maria WielsøeEva Cecilie Bonefeld-Jørgensen
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Jul 10, 2021·International Journal of Hygiene and Environmental Health·Nis-Julius SontagDaniel S Drage
Oct 17, 2021·The Science of the Total Environment·Sara SousaValentina F Domingues

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