Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention

Acta Pharmaceutica Sinica. B
Rajesh BasnetMing-Wei Wang

Abstract

The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.

Citations

Mar 22, 2019·Expert Opinion on Therapeutic Patents·Simona Sestito, Simona Rapposelli
Jul 3, 2019·ChemMedChem·Jens SchoeneMarc Nazaré
Jun 28, 2020·Experimental & Molecular Medicine·Seonghee JungSeong-Woon Yu
Jul 8, 2020·International Journal of Molecular Sciences·Boris Y ShorningHelen B Pearson
Feb 24, 2021·Cell Communication and Signaling : CCS·Raquel A C MachadoElisabeth Schaffner-Reckinger
May 29, 2021·Frontiers in Cell and Developmental Biology·Bang LiuZuping He
Oct 31, 2021·Experimental Dermatology·Gennie L ParkmanMartin McMahon

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Methods Mentioned

BETA
ubiquitination
xenograft

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AKT Pathway

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