Serum and liver iron concentration in dogs with experimentally induced hepatopathy

Journal of Gastroenterology and Hepatology
Nektarios SoubasisGeorgia Brellou

Abstract

Iron (Fe) status is altered in human and experimental animal hepatopathies. In dogs limited data are available. The aim of this study was to investigate serum iron (SI), total iron binding capacity (TIBC), percentage transferrin saturation (SAT) and Fe status in the liver of dogs with experimentally induced hepatopathy. Fourteen 1-year-old dogs were divided into two equal groups. In order for hepatopathy to be induced, 0.25 mL/kg body weight of carbon tetrachloride (CCl4) solution was administered once daily, orally, for a 10-week period in group B dogs, while group A dogs were used as controls. SI, TIBC and SAT values were measured 3 times before the beginning (baseline value) and 10 times at weekly intervals during the experiment. Liver samples, obtained before the administration of CCl4 and at the end of the experimental period (10 weeks), were subjected to Fe determination, as well as to histopathological and histochemical analysis. At the end of the experiment SI, TIBC and liver iron concentration, as well as liver total iron score were significantly increased in group B dogs. Distribution of granular hemosiderin iron in hepatocytes, Kupffer cells, and portal triads was noticed. Positive correlations were found between SI ...Continue Reading

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Citations

Oct 1, 2011·Clinical and Experimental Pharmacology & Physiology·Riccarda DelfinoLorella Pascolo
Jan 20, 2012·Australian Veterinary Journal·A PetersG P Eggins
Mar 7, 2014·The Journal of Small Animal Practice·S KilpatrickA G Gow
Oct 18, 2016·The Journal of Small Animal Practice·Y CedeñoM Miranda
May 16, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jacqueline C WhittemoreAnn Reed
Jan 16, 2021·Veterinary Clinical Pathology·Carol E Haak, Julie L Webb

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