PMID: 8587152Oct 1, 1995Paper

Serum and milk concentrations of apramycin in lactating cows, ewes and goats

Journal of Veterinary Pharmacology and Therapeutics
G ZivA Glickman

Abstract

A 20% solution of apramycin was administered intravenously (i.v.) and intramuscularly (i.m.) to lactating cows with clinically normal and acutely inflamed udders, to lactating ewes with normal or subclinically infected, inflamed udders and i.v. to lactating goats with normal udders. The i.v. disposition kinetics of apramycin was very similar in cows, ewes and goats. The elimination half-life was approximately 2 h and the steady-state volume of distribution was 1.26-1.45 L/kg. The absorption rate of the drug from the i.m. injection site was rapid, the i.m. bioavailability was 60-70% and the mean elimination half-life was 265 min in cows and 145.5 min in ewes. The binding percentage of apramycin to serum protein was low (< 22.5%). Concentrations of apramycin in milk produced by clinically normal mammary glands of cows, ewes and goats were consistently lower than in serum; the kinetic value AUCmilk/AUCserum was < 0.32. Drug penetration into the milk from the acutely inflamed quarters of cows was extensive; mastitis milk Cmax values were more than tenfold greater than the Cmax in normal milk. On the other hand, the drug had limited access to the milk produced by subclinically infected inflamed half-udders of ewes.

References

Dec 1, 1978·Journal of Pharmaceutical Sciences·R D Brown, J E Manno
May 1, 1976·The British Veterinary Journal·G ZivS Bernstein
Nov 19, 1988·The Veterinary Record·J N Prescott
Feb 1, 1985·Journal of Pharmaceutical Sciences·F C LamD G Perrier
Mar 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·G ZivJ F Nouws
Sep 1, 1973·Antimicrobial Agents and Chemotherapy·G Ziv, F G Sulman
Mar 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsG Ziv
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K K Chan, M Gibaldi

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Citations

Sep 29, 2007·The Veterinary Journal·A Goudah
Jan 24, 2009·Journal of Veterinary Pharmacology and Therapeutics·A Goudah, K Abo-El-Sooud
Jul 19, 2006·Journal of Veterinary Pharmacology and Therapeutics·A GoudahA M Abd El-Aty
Jan 29, 2019·The Journal of Antimicrobial Chemotherapy·Stefan RiedelJames E Kirby
Nov 30, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A GoudahA M Abd El-Aty
Jan 1, 2010·Journal of Equine Science·Maria Federica TrombettaAdalberto Falaschini

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