PMID: 6538310Apr 1, 1984Paper

Serum and muscle potassium in experimental alcoholic myopathy

Neurology
R G HallerJ P Knochel

Abstract

We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or elevated even in the presence of scattered muscle fiber necrosis. Increasing dietary potassium raised serum potassium but did not prevent EAM. These data indicate that hypokalemia in EAM is due to potassium redistribution between intra- and extracellular compartments rather than potassium deficiency, and confirm clinical observations that alcohol-induced muscle injury occurs independently of potassium deficiency.

Citations

Jun 22, 2001·Drug and Alcohol Dependence·V R PreedyT J Peters
Feb 3, 1998·Neuromuscular Disorders : NMD·M K ShariefM Swash
Aug 17, 1989·The New England Journal of Medicine·M E CharnessD A Greenberg
Mar 1, 1989·Medical Toxicology and Adverse Drug Experience·C Köppel
Aug 26, 1998·Journal of Toxicology. Clinical Toxicology·J FinstererB Mamoli
Sep 10, 2010·The American Journal of Emergency Medicine·Youichi YanagawaTomonori Imamura
Jan 28, 2003·Muscle & Nerve·Joern P Sieb, Thomas Gillessen
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V R PreedyT J Peters
Sep 16, 1985·Klinische Wochenschrift·A HeidlandE Heidbreder
Oct 21, 2000·Renal Failure·Z XieJ I Shapiro

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