Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

The British Journal of Dermatology
S AliJ F Setterfield

Abstract

The use of saliva for the diagnosis of pemphigus vulgaris (PV) by enzyme-linked immunosorbent assay (ELISA) using desmoglein (Dsg)3 antigen has not been extensively documented, nor has the detection of serum IgA antibodies to Dsg3. (i) To establish whether whole saliva might provide a suitable alternative to serum for diagnosing and monitoring PV; (ii) to investigate whether anti-Dsg3 IgA antibodies can be detected in serum and saliva and (iii) to establish whether there is an association between serum or saliva anti-Dsg3 antibodies and disease severity. Precoated Dsg3 ELISA plates were used to test serum and/or saliva for IgG and IgA antibodies. Matched serum and whole saliva samples were collected from 23 patients with PV, 17 healthy subjects and 19 disease controls. All patients with PV, disease controls and six healthy controls provided matched parotid saliva. Whole saliva IgG antibodies to Dsg3 were detected in 14 of 23 patients (61%) and serum IgG antibodies were detected in 17 of 23 (74%) with a strong positive correlation. Serum IgA antibodies were detected in 14 of 23 patients with PV (61%) with a combined positivity (IgG and/or IgA antibodies to Dsg3) of 78% (18 of 23). We were unable to show IgA anti-Dsg3 antibodies ...Continue Reading

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Citations

Oct 30, 2016·Experimental Dermatology·A Razzaque AhmedSergei A Grando
Dec 27, 2018·The British Journal of Dermatology·S SunX Zeng
Dec 2, 2017·The British Journal of Dermatology·K E HarmanP D Yesudian
Jun 12, 2018·BioMed Research International·Farah Asa'adGiovanni Damiani
Dec 6, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Emily F ColeRon J Feldman
Feb 13, 2020·Journal of Clinical Medicine·Emanuela MartinaAnnamaria Offidani
Jul 7, 2018·Journal of Immunology Research·Matteo SaccucciAntonella Polimeni
Jan 4, 2018·The British Journal of Dermatology·M OrmondJ F Setterfield
Jul 3, 2021·International Journal of Molecular Sciences·Anna CampanatiAnnamaria Offidani
Jul 12, 2021·The Journal of Investigative Dermatology·Shirin EmtenaniChristoph M Hammers

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