PMID: 6171904Jul 1, 1981Paper

Serum and sputum alpha 2 macroglobulin in patients with chronic obstructive airways disease

Thorax
D Burnett, R A Stockley

Abstract

Serum alpha 2 macroglobulin concentrations were measured in patients with chronic obstructive airways disease and an age-matched group of control subjects. The mean serum level of alpha 2 macroglobulin was significantly lower in bronchitic subjects with acute chest infections than the mean value of the controls. No significant differences were observed between serum alpha 2 macroglobulin values in controls, subjects with "emphysema", and bronchitic patients who did not have chest infections. Sputum alpha 2 macroglobulin concentrations were compared in sputum samples from bronchitic patients with and without acute chest infections. The protein was detected (greater than 0.2 mg/l) in 94% of sputum samples from infected subjects but only 60% of non-infected sputum samples. Concentrations of alpha 2 macroglobulin in infected samples were significantly higher than the non-infected samples. Sputum/serum concentration ratios of alpha 2 macroglobulin were also significantly higher in infected samples but this difference was eliminated by "correcting" the values with the albumin sputum/serum ratios of the same samples. The results suggest that alpha 2 macroglobulin concentrations are higher in bronchial secretions during chest infection...Continue Reading

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Citations

Jan 1, 1987·Archives of Oto-rhino-laryngology·Y Hamaguchi, S K Juhn
Jan 1, 1988·Lung·C G Persson
Nov 17, 2009·Pediatric Cardiology·Ramachandran MeenakshisundaramPonniah Thirumalaikolundusubramanian
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Aug 1, 1995·Infection and Immunity·H P Müller, L K Rantamäki

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