Serum and synovial fluid concentrations of keratan sulfate and hyaluronan in dogs with induced stifle joint osteoarthritis following cranial cruciate ligament transection

American Journal of Veterinary Research
Steven C BudsbergEugene J-M A Thonar

Abstract

To examine longitudinal changes in serum and synovial fluid concentrations of keratan sulfate (KS) and hyaluronan (HA) after cranial cruciate ligament (CCL) transection in dogs. 12 clinically normal adult mixed-breed dogs. Following CCL transection in the right stifle joint, KS and HA concentrations were determined in serum and neat (undiluted) synovial fluid prior to and 1, 2, 3, and 12 months after surgery. Postsurgical dilution of synovial fluid was corrected by use of urea as a passive marker. Synovial fluid KS and HA concentrations decreased at 1, 2, and 3 months after surgery in operated stifle joints, compared with baseline values. Synovial fluid KS concentration decreased in unoperated stifle joints at 1 month. A decrease in synovial fluid KS concentration was found in operated stifle joints, compared with unoperated stifle joints, at 2 and 3 months, and a decrease in synovial fluid HA concentrations was also found in operated stifle joints, compared with unoperated stifle joints, at 1, 2, and 3 months. Serum KS concentrations increased from baseline values at 3 months after surgery. Hyaluronan concentrations in operated stifle joints were lower than baseline values at 1, 2, and 3 months. Urea-adjusted synovial fluid co...Continue Reading

References

May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A RatcliffeT E Hardingham
Dec 1, 1985·Arthritis and Rheumatism·E J ThonarK E Kuettner
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A RatcliffeF Saed-Nejad
Jul 1, 1995·Arthritis and Rheumatism·P K HazellT E Hardingham
Mar 1, 1995·Osteoarthritis and Cartilage·H RoosL S Lohmander
May 1, 1994·Research in Veterinary Science·M AricanC May
Oct 1, 1996·British Journal of Rheumatology·M SharifP A Dieppe
May 18, 1999·Osteoarthritis and Cartilage·E J Thonar
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E LindhorstV B Kraus
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F C RobionS Laverty
Feb 13, 2002·Arthritis and Rheumatism·Virginia B KrausFarshid Guilak
Aug 31, 2002·Osteoarthritis and Cartilage·N HegemannM F Schmidt

❮ Previous
Next ❯

Citations

Dec 10, 2009·Rheumatology·Shigeyuki WakitaniYusuke Hashimoto
Oct 6, 2009·The Journal of Veterinary Medical Science·Hideyuki KanemotoHajime Tsujimoto
Dec 25, 2012·Research in Veterinary Science·H D PlickertL Brunnberg
May 22, 2010·The Veterinary Journal·Elaine R GarvicanJohn F Innes
Jul 3, 2013·Journal of Veterinary Science·Korakot NganvongpanitPatsanan Markmee
Aug 22, 2008·Journal of Veterinary Science·Korakot NganvongpanitPrachya Kongtawelert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Comparative Pathology
M AricanD Bennett
Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Graham Tytherleigh-StrongAnthony Miniaci
© 2021 Meta ULC. All rights reserved