PMID: 11929711Apr 4, 2002Paper

Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma

Hepatology Research : the Official Journal of the Japan Society of Hepatology
M TamanoA Terano

Abstract

A sensitive method for measuring the serum level of protein-induced by vitamin K absence or antagonist II (PIVKA-II) has become so widely available that it is now used for the clinical diagnosis of small hepatocellular carcinoma (HCC). It is known that serum PIVKA-II can be a prognostic indicator for HCC, but there have been no detailed investigations concerning the tissue expression of PIVKA-II. The present study assessed the relationship between serum or tissue PIVKA-II and the biological malignant potential of HCC. The subjects were 25 patients with histologically confirmed HCC, that were solitary and 3 cm or less in diameter. Tissue PIVKA-II was detected by immunostaining using MU-3 as the primary antibody. The biological malignant potential of the tumors was evaluated on the basis of the Ki-67 labeling index of HCC cells and the tumor arterial vascularity assesed by angiography and CO(2) enhanced ultrasonography. The recurrence-free period after treatment was also evaluated. Among the 25 patients, eight were positive for tissue PIVKA-II. Serum PIVKA-II levels were significantly higher in the tissue PIVKA-II-positive patients compared with the negative patients, but serum and tissue PIVKA-II expressions were not consistentl...Continue Reading

Citations

Mar 10, 2010·Journal of Surgical Oncology·Atsushi NanashimaTakeshi Nagayasu
Oct 28, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Sunyoung LeeKyoung Doo Song
Dec 28, 2017·Cancer Biomarkers : Section a of Disease Markers·Gabriele RiccoMaurizia Rossana Brunetto
Dec 8, 2004·The Journal of Biological Chemistry·Mayumi SuzukiYasushi Shiratori
Jan 27, 2007·The Journal of Biological Chemistry·Tatsuya FujikawaYasushi Shiratori
Sep 30, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Yoshinori InagakiNorihiro Kokudo
Nov 11, 2018·Molecular Genetics and Metabolism·Katell Peoc'hJean-Charles Deybach
Jul 16, 2010·Orphanet Journal of Rare Diseases·Mariasanta NapolitanoMario Lapecorella

❮ Previous
Next ❯