PMID: 2040092Apr 1, 1991Paper

Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction

Clinical Biochemistry
T TanakaK Kawamura

Abstract

A competitive enzyme immunoassay (C-EIA) was developed for the measurement of serum and urinary levels of human heart fatty acid-binding protein (hh-FABP), and the appearance and time-course changes of hh-FABP levels were evaluated in patients with acute myocardial infarction (AMI). Control serum and urinary hh-FABP levels, which were determined in 86 serum and 42 urine samples from 86 patients without AMI, were found to range between 0 and 2.8 ng/mL. Serial determinations performed on 11 patients with AMI demonstrated that hh-FABP levels were significantly elevated in the first serum and urine samples obtained within 14 h of the onset of clinical symptoms. Two serum and 2 urine samples obtained only 1.5 h after the onset of symptoms already showed elevated hh-FABP levels, while in the same serum samples the activity of the myocardial-specific isoenzyme of creatine kinase (CK-MB) was still normal. Maximal serum and urinary hh-FABP levels appeared between 5 and 10 h after symptoms developed, and fell sharply towards normal thereafter. The hh-FABP levels in serum and urine both peaked earlier than the elevation of CK-MB activity in serum. The presence of hh-FABP in serum and/or urine seems to be a marker for myocardial damage and...Continue Reading

References

Jul 1, 1979·European Journal of Biochemistry·T TanakaS Numa
Oct 1, 1989·Journal of the American College of Cardiology·N U BangM D Clayman
May 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·J X WangD A Mickle
Jun 1, 1989·Journal of Molecular and Cellular Cardiology·A A KnowltonP Brecher
Aug 1, 1988·Archives of Biochemistry and Biophysics·R J PaulussenJ H Veerkamp
Jun 30, 1986·Biochemical and Biophysical Research Communications·N M Bass, J A Manning
Dec 28, 1971·Journal of Molecular Biology·J King, U K Laemmli

❮ Previous
Next ❯

Citations

Jun 9, 1993·Molecular and Cellular Biochemistry·P G VoldersJ F Smits
Oct 7, 2009·Endocrine·Erdem AkbalTuncay Delibaşı
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong LiuHua Jing
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·A H Wu
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F GlatzW T Hermens
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J IshiiK Kawamura
Jun 1, 1997·Clinical Biochemistry·A H Wu
Sep 1, 1996·Progress in Lipid Research·J F Glatz, G J van der Vusse
Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T PetzoldE Gams
May 31, 2008·Nature Reviews. Drug Discovery·Masato Furuhashi, Gökhan S Hotamisligil
Apr 21, 2011·Human Genomics·Rebecca L Smathers, Dennis R Petersen
Feb 5, 2013·Critical Care : the Official Journal of the Critical Care Forum·Chi-Lun HuangWei-Shiung Yang
Jun 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Anthony S McLeanMark Salter
Jan 28, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiko SeinoUNKNOWN Tokyo Rapid-Test Office Cardiologists (Tokyo-ROC) Study
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato FuruhashiKazuaki Shimamoto
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi HazuiToshiaki Hanafusa
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi SetsutaKyoichi Mizuno
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K W WodzigM P van Dieijen-Visser
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·J Mair
Sep 7, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela CardinaleMaria T Sandri
Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
Jul 10, 2008·Current Cardiology Reports·Frances O Wood, James A de Lemos
May 13, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Akihiro ShirakabeWataru Shimizu
Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·H A Alhadi, K A A Fox
Nov 10, 2005·Cardiology Clinics·Allan S Jaffe
Apr 20, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tatsuya KusudoHitoshi Yamashita
Jan 4, 2005·Journal of Immunological Methods·D van der VoortJ F C Glatz
Jan 1, 1993·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·A H KleineF Bosman
Dec 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J H VeerkampC F Prinsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.