PMID: 7527229Sep 1, 1994Paper

Serum and urine inorganic fluoride levels following prolonged low-dose sevoflurane anesthesia combined with epidural block

Journal of Clinical Anesthesia
C MatsumuraT Mayumi

Abstract

To determine whether serum and urine inorganic fluoride levels with prolonged (more than 7 hours) low-dose (0.8 to 2.0 vol %) sevoflurane anesthesia plus epidural anesthesia were increased as compared with isoflurane anesthesia plus epidural anesthesia. To measure the urine tubular enzymes N-acetyl-beta-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M), and beta 2-microglobulin (beta 2-M) for renal tubular injury in both groups. Randomized, prospective study. University hospital. 15 ASA physical status I and II adults (7 males, 8 females) who were scheduled for prolonged laparotomy (lasting 9.5 to 10.2 hours) with general anesthesia. Epidural anesthesia was administered before induction of general anesthesia. General anesthesia was induced with thiamylal administered intravenously (IV), and the trachea was intubated following administration of vecuronium IV. It was maintained with either sevoflurane or isoflurane in nitrous oxide and oxygen. Standard monitoring was used in all patients. Serum and urine inorganic fluoride and urine tubular enzymes were measured periodically. Serum inorganic fluoride was 54 mumol/L at 4.3 minimum alveolar concentration (MAC) hours of sevoflurane; the peak level for isoflurane was 8 mumol/L...Continue Reading

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Citations

Nov 1, 1995·Journal of Clinical Anesthesia·C J Young, J L Apfelbaum
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Florian M Reichle, Peter F Conzen
Aug 20, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rakesh V SondekoppamTimur J-P Özelsel
Mar 1, 1997·The Journal of International Medical Research·A NishimoriM Kim
Mar 3, 2021·Anesthesia and Analgesia·Shigemasa Ikeda, Hiroshi Makino

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