Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Marios PapasotiriouPeter Boor

Abstract

The extent of renal fibrosis in chronic kidney disease (CKD) is the best predictor for progression of most renal diseases. To date, no established biomarkers of renal fibrosis exist. We measured circulating and urinary-specific matrix metalloproteinase (MMP)-generated collagen type I and III degradation fragments (C1M and C3M) and an N-terminal propeptide of collagen III (Pro-C3), as markers of collagen type III production, in three rat models of CKD and fibrosis: renal mass reduction (5/6 nephrectomy), progressive glomerulonephritis (chronic anti-Thy1.1 nephritis) and adenine crystal-induced nephropathy. Healthy rats served as controls. In all three models, the animals developed significant CKD and renal fibrosis. Compared with healthy rats, serum C1M and C3M significantly increased in rats with 5/6 nephrectomy and adenine nephropathy (2- to 3-fold), but not with chronic anti-Thy1.1 nephritis. Urinary C1M and C3M levels increased 9- to 100-fold in all three models compared with controls. Urinary degradation markers correlated closely with renal deposition of collagen type I and type III. Pro-C3 was significantly increased only in the urine of 5/6 nephrectomy rats. In particular, urinary markers of MMP-driven collagen degradati...Continue Reading

References

Jan 1, 1986·Nephron·T YokozawaF Koizumi
Mar 3, 2006·Journal of the American Society of Nephrology : JASN·Tammo OstendorfJürgen Floege
Dec 28, 2006·American Journal of Physiology. Renal Physiology·J M CataniaA R Parrish
Feb 20, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter BoorJürgen Floege
Apr 3, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A GressnerAxel M Gressner
Aug 1, 2008·Arthritis and Rheumatism·Eugene Y ZhenKevin L Duffin
Jan 22, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Balsam El GhoulFadi Fakhouri
Jul 10, 2010·Molecular & Cellular Proteomics : MCP·David M GoodPhilippe Schmitt-Kopplin
Jul 30, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Sanne S VeidalMorten A Karsdal
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Jan 22, 2011·Circulation Research·Ellen Neven, Patrick C D'Haese
May 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Santo DellegrottaglieSanjay Rajagopalan
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dj LeemingMa Karsdal
Apr 12, 2012·American Journal of Physiology. Renal Physiology·Roderick J Tan, Youhua Liu
Aug 9, 2012·Diabetes·Petra ZürbigPeter Rossing
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Motoko Yanagita
Mar 20, 2014·Nature Reviews. Nephrology·Toshio MiyataMasahiro Takeuchi
Apr 1, 2014·Fibrogenesis & Tissue Repair·Federica GenovesePeter Boor

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Citations

Aug 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Federica GenoveseJürgen Floege
Apr 22, 2017·PloS One·Elisabeth G D StribosFederica Genovese
Oct 19, 2017·Expert Review of Proteomics·Sarah Röthlisberger, Johanna Pedroza-Diaz
Oct 17, 2018·The Journal of Physiology·Sandor KoszegiAndrea Fekete
May 23, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Roman David Bülow, Peter Boor
Sep 25, 2019·Nature Reviews. Drug Discovery·Xiao ZhaoFei-Fei Liu
Dec 10, 2019·Tropical Medicine & International Health : TM & IH·Arun Kumar KarayiRajendra Pilankatta
Mar 23, 2017·Journal of Translational Medicine·Ryanne S HijmansJacob van den Born
Dec 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Guldager Kring RasmussenRikke Nørregaard
Aug 17, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Wei WangZhihong Liu
Feb 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiuxia SunJianxi Xiao
May 27, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Per Mose NielsenChristoffer Laustsen
Aug 6, 2020·Frontiers in Medicine·Peter StankoFedor Simko
Nov 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangdong CaiJianxi Xiao
Nov 7, 2019·Scientific Reports·Daniel Guldager Kring RasmussenFederica Genovese
Apr 5, 2019·Science Translational Medicine·Qinxue SunPeter Boor
Jan 28, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Mengkui SunShoulin Li
Feb 23, 2021·Drug Discovery Today·Anjali SrivastavaShrikant R Mulay
Jul 1, 2021·Nature Reviews. Nephrology·Barbara M KlinkhammerPeter Boor
Jun 6, 2020·Journal of Proteome Research·Julian L KesslerS Michael Yu
Nov 8, 2017·Advanced Drug Delivery Reviews·Maike BauesTwan Lammers

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