Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus

Journal of Diabetes and Its Complications
Li LiZheng-Qing Yu

Abstract

The aim of the present study was to investigate the association of serum levels of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) with angiopathy in type 2 diabetes mellitus (T2DM). The group studied comprised of 120 patients with T2DM (68 males and 52 females), included macroangiopathy complications, microvascular disease and diabetic without vascular disease. The control group consisted of 50 healthy blood donors. Ang-1, Ang-2, fasting plasma glucose (FBG), fasting insulin (FINS) and HbA1c were assessed. The serum Ang-2 levels of T2DM patients with angiopathy were found to be significantly higher compared to patients without angiopathy. Ang-2 levels were significantly positively correlated with homeostasis model assessment for insulin resistance (HOMA-IR) and glycosylated hemoglobin A1c (HbA1c) (r=0.577 and 0.504, respectively, P<0.01). In contrast, there was no significant correlation between Ang-1 levels and HOMA-IR (P>0.05). In multivariable logistic regression analysis, Ang-2 levels (P=0.02) were found to be independently associated with patients with T2DM angiopathy. An association between the Ang-2 and T2DM with vascular complications was found.

References

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M ValenzuelaG D Yancopoulos
Oct 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tamami OkamotoZenji Makita
Apr 3, 2008·Annals of Medicine·Jeetesh V PatelGregory Y H Lip
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tibor SzarvasHerbert Rübben
May 19, 2009·Angiogenesis·Markus Thomas, Hellmut G Augustin
Jun 28, 2011·Cardiovascular Diabetology·Sazan RasulAlexandra Kautzky-Willer
Jan 25, 2012·PloS One·Sophie CalderariEtienne Larger
May 15, 2013·Virulence·Andrea V Page, W Conrad Liles

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Citations

Dec 15, 2015·Journal of Diabetes and Its Complications·Li LiJin Meng
Oct 26, 2016·Journal of Diabetes and Metabolic Disorders·Kwame YeboahAlbert G B Amoah
May 23, 2017·Nature Reviews. Drug Discovery·Pipsa SaharinenKari Alitalo
Mar 8, 2018·Journal of Exercise Rehabilitation·Hyuek Jong Lee
Apr 21, 2017·Frontiers in Physiology·Carlos A EscuderoMarcelo González
Jan 18, 2019·Nature·Reiner A WimmerJosef M Penninger
Feb 21, 2019·Scientific Reports·Alexander W W Langford-SmithM Yvonne Alexander
Jan 21, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Jelizaveta SokolovskaPeteris Tretjakovs
Jan 26, 2021·Frontiers in Cardiovascular Medicine·Clément MercierPedro Geraldes
Jul 3, 2021·Journal of Clinical Medicine·Angelo CignarelliFrancesco Giorgino

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