Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Andrew S AllegrettiRaymond T Chung

Abstract

Acute kidney injury in decompensated cirrhosis has limited therapeutic options, and novel mechanistic targets are urgently needed. Angiopoietin-2 is a context-specific antagonist of Tie2, a receptor that signals vascular quiescence. Considering the prominence of vascular destabilization in decompensated cirrhosis, we evaluated Angiopoietin-2 to predict clinical outcomes. Serum Angiopoietin-2 was measured serially in a prospective cohort of hospitalized patients with decompensated cirrhosis and acute kidney injury. Clinical characteristics and outcomes were examined over a 90-day period and analyzed according to Angiopoietin-2 levels. Primary outcome was 90-day mortality. Our study included 191 inpatients (median Angiopoietin-2 level 18.2 [interquartile range 11.8, 26.5] ng/mL). Median Model for End-Stage Liver Disease (MELD) score was 23 [17, 30] and 90-day mortality was 41%. Increased Angiopoietin-2 levels were associated with increased mortality (died 21.9 [13.9, 30.3] ng/mL vs. alive 15.2 [9.8, 23.0] ng/mL; P < 0.001), higher Acute Kidney Injury Network stage (stage I 13.4 [9.8, 20.1] ng/mL vs. stage II 20.0 [14.1, 26.2] ng/mL vs. stage III 21.9 [13.0, 29.5] ng/mL; P = 0.002), and need for renal replacement therapy (16.5 [11...Continue Reading

References

Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Oct 7, 1997·Circulation Research·A L WongK G Peters
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Javier FernándezJuan Rodés
Jan 4, 2003·Gastroenterology·Russell WiesnerUNKNOWN United Network for Organ Sharing Liver Disease Severity Score Committee
Jan 25, 2005·Journal of Hepatology·Hermann E WasmuthFrank Lammert
Apr 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlo AlessandriaPere Ginès
Sep 6, 2005·Journal of Hepatology·Agustín AlbillosLuis-Miguel Molinero
Jun 22, 2007·The American Journal of Gastroenterology·Arne ScholzEckart Schott
Sep 5, 2008·The New England Journal of Medicine·W Ray KimTerry M Therneau
Sep 25, 2009·The New England Journal of Medicine·Pere Ginès, Robert W Schrier
Oct 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·André NazarPere Ginès
Aug 19, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J PencinaRamachandran S Vasan
Dec 15, 2010·Journal of Hepatology·Mauro BernardiMaurizio Biselli
Nov 29, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesco CorradiMiquel Navasa
Aug 15, 2012·Critical Care Medicine·Sascha DavidSamir M Parikh
Mar 12, 2013·Gastroenterology·Richard MoreauUNKNOWN CANONIC Study Investigators of the EASL–CLIF Consortium
Jul 19, 2013·The Journal of Clinical Investigation·Tilman ZieglerChristian Kupatt
Aug 14, 2013·PloS One·Andrew V BenestHellmut G Augustin
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rogelio BarretoPere Ginès
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Fan-Chi ChangShuei-Liong Lin
Mar 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Montse PautaManuel Morales-Ruiz
Jun 21, 2014·Journal of Hepatology·Rajiv JalanUNKNOWN CANONIC study investigators of the EASL-CLIF Consortium
Sep 10, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Minjong LeeHyo-Suk Lee
Nov 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter JepsenPer Kragh Andersen
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chandra C GhoshSamir M Parikh
Mar 19, 2016·Journal of Hepatology·X ArizaUNKNOWN CANONIC Investigators, EASL CLIF Consortium
Apr 22, 2016·Science Translational Medicine·Samir M Parikh
Apr 22, 2016·Science Translational Medicine·Sangyeul HanGou Young Koh
May 24, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Oriol JuanolaRubén Francés
Aug 3, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joan ClàriaUNKNOWN CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (
Sep 23, 2016·Digestive Diseases and Sciences·Andrew S AllegrettiRavi I Thadhani
Jan 6, 2017·Gut·Ruben HernaezPere Ginès
Aug 29, 2017·Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology·Alexandra AlexopoulouSpyros P Dourakis
Jan 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Tomokazu SoumaSusan E Quaggin
Jan 24, 2018·The Journal of Clinical Investigation·Sarah J HigginsSamir M Parikh
Jan 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael M YeboahJohn D Imig
Feb 3, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Salvatore PianoUNKNOWN EASL CLIF Consortium, European Foundation for the Study of Chronic Liver Failure (EF Clif)

❮ Previous
Next ❯

Citations

Feb 6, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoki KawagishiNaoya Sakamoto
Jan 1, 2020·International Journal of Molecular Sciences·Kohshiro HosokawaHajime Isomoto
Mar 8, 2020·Nature Reviews. Nephrology·Katsuyuki TanabeYasufumi Sato
Oct 27, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Taku ShigesawaNaoya Sakamoto
Feb 10, 2021·BMC Gastroenterology·Yosuke OsawaTatsuya Kanto
May 13, 2021·Clinical and Translational Gastroenterology·Andrew S AllegrettiUNKNOWN HRS-HARMONY study investigators
Jul 9, 2021·Alimentary Pharmacology & Therapeutics·Andrew S AllegrettiKevin Moore
Nov 12, 2021·The Journal of Medical Investigation : JMI·Natsuda AumpanSith Siramolpiwat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
Kristof NagyMiklos Z Molnar
Liver International : Official Journal of the International Association for the Study of the Liver
Ana Garcia Garcia de ParedesAgustín Albillos
© 2022 Meta ULC. All rights reserved