PMID: 8938630Oct 1, 1996Paper

Serum angiotensin converting enzyme and C4 protein of complement as a combined diagnostic index in alcoholic liver disease

Liver
B SopeñaJ Prieto

Abstract

Diagnosis of liver cirrhosis relies on hepatic biopsy. So far, attempts have failed to achieve a serologic test that differentiates cirrhosis from other hepatic conditions. The aim of this work was to assess the diagnostic value of the ratio of serum angiotensin converting enzyme activity (SACE) and the levels of protein C4 of serum complement (SACE/C4) in differentiating cirrhotic from noncirrhotic alcoholic liver diseases. In this study, 68 active alcoholic patients (17 with fatty liver or minimal changes, 11 with acute alcoholic hepatitis and 40 with cirrhosis) were included. Twenty healthy subjects were studied as a control group. Liver biopsy was performed in all patients. SACE levels were significantly higher in the group with cirrhosis when compared with the group of patients without cirrhosis and the control. On the other hand, serum C4 level decreased as liver damage progressed. SACE values above 25 IU/l had a sensitivity of 92.5 percent (95 percent confidence interval, 87.5 to 97.5) and a specificity of 79 percent (95% percent confidence interval, 70.5 to 87.5), in detecting those patients with liver cirrhosis. The sensitivity further increased to 95 percent (95 percent confidence interval, 90.5 to 99.5) and the speci...Continue Reading

References

Jun 24, 1976·The New England Journal of Medicine·J Lieberman, E Beutler
Oct 1, 1978·Alcoholism, Clinical and Experimental Research·J G RankinA I Armstrong
Feb 1, 1988·Seminars in Liver Disease·W C Maddrey
Oct 1, 1986·Annals of Internal Medicine·V K Rocco, A J Ware
Mar 1, 1985·The Journal of Clinical Investigation·T OkabeB L Fanburg
Feb 1, 1988·Seminars in Liver Disease·B F GrantT C Harford
Oct 1, 1982·The American Journal of Medicine·K Matsuki, T Sakata
Apr 4, 1981·British Medical Journal·J B SaundersR Williams
Jan 15, 1993·Annals of Internal Medicine·C H Janes, K D Lindor

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Citations

Apr 2, 2019·Psychiatric Genetics·Ruo-Nan JiChang-Gui Kou
Jun 11, 2021·Immunology Letters·Lazara Elena Santiesteban-LoresLorena Bavia

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