Serum antibodies against membranous labyrinth in patients with "idiopathic" bilateral vestibulopathy

Journal of Neurology
V ArbusowT Brandt

Abstract

To investigate the possibility of an autoimmune mechanism in idiopathic bilateral vestibulopathy (IBV), we screened patients' sera for antibodies against inner ear structures. IgG antibodies against membranous labyrinth (ampulla, semicircular canals, saccule and utricle) were detected in 8 of 12 patients by immunofluorescence on rat inner ear cryosections. All but one serum of 22 healthy controls and the sera of 6 patients with known autoimmune disorders showed only background staining. Low-titre anti-nuclear IgM antibodies were present in three control sera and one IBV serum. High-titre anti-nuclear IgM was found in a patient with lupus erythematosus and in one with scleroderma. Anti-nuclear IgM was not organ-specific. No human serum used contained detectable anti-vascular preformed antibodies. Cross-reactivity to sections of liver, kidney, cornea, brain and skeletal muscle was absent. Double-staining for IgG and F-actin, the primary constituent of hair cell cilia, did not show predominant Ig-coating of sensory hair cells. Immunosuppressive therapy in 3 IBV patients did not improve the disorder, probably owing to irreversible loss of sensory and neural structures. These data suggest that the bulk of anti-labyrinthine autoantib...Continue Reading

References

Sep 1, 1979·The Annals of Otology, Rhinology, and Laryngology·B F McCabe
May 22, 1992·Annals of the New York Academy of Sciences·T Brandt, M Dieterich
Dec 1, 1990·Immunology Today·J L PlattF H Bach
Feb 1, 1989·Neurology·R W BalohV Honrubia
Jan 1, 1987·The Laryngoscope·J P Harris
Feb 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G B HughesL H Calabrese
May 1, 1983·The Annals of Otology, Rhinology, and Laryngology·T J YooA H Kang
Sep 1, 1995·Acta Oto-laryngologica·D VibertR Häusler
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Y CaoJ P Tomasi

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Citations

Sep 1, 2014·Autoimmunity Reviews·Antonio GrecoMarco de Vincentiis
Jan 18, 2006·Current Opinion in Neurology·Charlotte Agrup, Linda M Luxon
Feb 24, 2009·La Revue de médecine interne·B HervierM Hamidou
Sep 15, 2005·Acta Oto-laryngologica·Angela DeutschländerThomas Brandt
Apr 13, 2005·Acta Oto-laryngologica·Chisato FujimotoToshihisa Murofushi
Jun 29, 2012·The Annals of Otology, Rhinology, and Laryngology·Chisato FujimotoShinichi Iwasaki
Oct 31, 2017·Journal of Vestibular Research : Equilibrium & Orientation·Michael StruppHerman Kingma
Oct 1, 2008·Journal of Neurology·Vera C ZinglerMichael Strupp
Jan 18, 2006·Current Opinion in Neurology·Michael Strupp, Thomas Brandt
Feb 15, 2001·Current Opinion in Neurology·A F RyanJ P Harris
Aug 21, 2019·Orphanet Journal of Rare Diseases·Chisato FujimotoToshihisa Murofushi
May 13, 2020·Journal of Neurology·Jae-Gyum KimJi-Soo Kim
Mar 30, 2007·Annals of Neurology·Vera C ZinglerMichael Strupp
Oct 3, 2018·Immunologic Research·Francesca Yoshie RussoAntonio Greco

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