Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children

Infection
M PasettiM Manghi

Abstract

The Argentine vaccination schedule against diphtheria, tetanus and pertussis (DTP) recommends three doses of DTP vaccine at 2, 4 and 6 months of age, two boosters at 18 months and 6 years, a booster dose of tetanus vaccine every 10 years and two doses during pregnancy. To evaluate the effect of this schedule, antibodies against pertussis toxin (PT) and filamentous hemagglutinin (FHA) and against tetanus and diphtheria toxoids were determined by ELISA in serum samples from children (1 month to 6 years) who received different doses of DPT vaccine: 0 dose (n = 50), 1 dose (n = 25), 2 doses (n = 25), 3 doses (n = 55), first and second booster (n = 25); 25 pregnant women and their offspring, and 45 adults. High antibody levels against PT (> 140 EU/ml) and FHA (> 80 EU/ml) were recorded in mothers and in the newborn. Antibody titers against PT increased with the number of doses given and decreased with time. Full protection against tetanus (titers > 0.1 IU/ml) was observed in the group of adults (0.37 IU/ml), in mothers (4.4 IU/ml) and their newborn offspring (5.5 IU/ml), and in children after receiving the second dose of DTP vaccine (1.86 IU/ml). The immune status for diphtheria was far lower, as most of the groups lacked adequate p...Continue Reading

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Citations

Dec 17, 2014·Clinical & Translational Immunology·Rajiv Kumar, Christian Engwerda
Feb 1, 2011·Therapeutic Delivery·Mohd SamimAmarnath Maitra
Apr 14, 2005·Public Health·T InandiN Hacialioglu
Oct 1, 2016·Human Vaccines & Immunotherapeutics·Jesús Zacarías Villarreal PérezAzucena M Rodríguez González
May 15, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Nikolaj W ØrntoftJane Agergaard

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