PMID: 7539580Jun 1, 1995Paper

Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus

American Journal of Hematology
A Ruiz-ArguellesP Gaussem

Abstract

Defective fibrinolysis due to decreased tissue-type plasminogen activator (t-PA) activity is a well-established finding in patients with systemic lupus erythematosus (SLE). The possibility that this decrease in t-PA activity may be related to the presence of autoantibodies directed against t-PA, and the possible role of these autoantibodies in the pathophysiology of fibrinolysis in SLE, were investigated. Serum samples from 115 SLE patients and 63 normal volunteers were analyzed for the presence of such antibodies. The search for antibodies to t-PA was performed by means of several systems, allowing for the identification of epitopes presented in different conformational physical states of t-PA: free or associated to its inhibitor (PAI-1) in plasma, specifically bound to fibrin surface, or passively adsorbed to solid supports. Antibodies in variable amounts were detected by all systems used; however, t-PA activity was not inhibited by the IgG fraction of the positive sera in a fibrin-agar fibrinolysis system. Moreover, the demonstration of serum anti-t-PA antibodies was not associated with clinical or laboratory abnormalities related to vasoocclusive episodes. These results indicate that, as in the case of other autoantibodies,...Continue Reading

References

Feb 1, 1971·The British Journal of Dermatology·W J Cunliffe, I S Menon
Feb 1, 1980·Annals of Internal Medicine·J R MuehS I Rapaport

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Citations

May 22, 1998·International Journal of Clinical & Laboratory Research·M CugnoI Martinelli
Feb 4, 2010·European Journal of Internal Medicine·Massimo CugnoPier Luigi Meroni
Aug 30, 2005·Annals of the New York Academy of Sciences·Emily C SomersW Joseph McCune
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·G J Ruiz-ArgüellesD Alarcón-Segovia
Jan 12, 1999·American Journal of Hematology·G J Ruiz-ArgüellesA Ruiz-Argüelles
Dec 15, 2015·Journal of Cardiovascular Pharmacology and Therapeutics·Mehmet ÖzkanMassimo Cugno

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