Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients.

PloS One
Charles E ShelburneDennis E Lopatin

Abstract

Chaperones are ubiquitous conserved proteins critical in stabilization of new proteins, repair/removal of defective proteins and immunodominant antigens in innate and adaptive immunity. Periodontal disease is a chronic inflammatory infection associated with infection by Porphyromonas gingivalis that culminates in the destruction of the supporting structures of the teeth. We previously reported studies of serum antibodies reactive with the human chaperone Hsp90 in gingivitis, a reversible form of gingival disease confined to the oral soft tissues. In those studies, antibodies were at their highest levels in subjects with the best oral health. We hypothesized that antibodies to the HSP90 homologue of P. gingivalis (HtpG) might be associated with protection/resistance against destructive periodontitis. ELISA assays using cloned HtpG and peptide antigens confirmed gingivitis subjects colonized with P. gingivalis had higher serum levels of anti-HtpG and, concomitantly, lower levels of attachment loss. Additionally, serum antibody levels to P. gingivalis HtpG protein were higher in healthy subjects compared to patients with either chronic or aggressive periodontitis. We found a negative association between tooth attachment loss and a...Continue Reading

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Citations

Mar 17, 2011·Journal of Dental Research·J S KinneyW V Giannobile
Mar 4, 2009·Journal of Periodontology·Christoph A RamseierWilliam V Giannobile
Mar 2, 2011·Journal of the American Veterinary Medical Association·Jennifer E RawlinsonColin E Harvey
Apr 13, 2015·International Journal of Cardiology·Damian Sanchez-TorresMartin Laclaustra
Dec 7, 2013·Journal of Clinical Periodontology·Janet S KinneyWilliam V Giannobile
Oct 2, 2015·Clinical Oral Implants Research·Hom-Lay WangWilliam V Giannobile
Dec 25, 2012·Journal of Medical Microbiology·Ji-Hoi MoonJin-Yong Lee
Jun 15, 2011·Veterinary Microbiology·Wei DangLi Sun
Jul 30, 2015·Journal of Applied Oral Science : Revista FOB·Nora SilvaJorge Gamonal
Aug 11, 2020·Journal of Periodontology·Liat ChaushuGavriel Chaushu
May 20, 2017·Frontiers in Microbiology·Vanessa CasasJoaquin Abian
Aug 17, 2019·International Journal of Molecular Sciences·C M FigueredoR M Love

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Datasets Mentioned

BETA
AF176245
EDK88176

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

BLAST

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